PDB entry 7avi

View 7avi on RCSB PDB site
Description: Crystal structure of SOS1 in complex with compound 2
Class: protein binding
Keywords: RasGEF, PROTEIN BINDING
Deposited on 2020-11-05, released 2021-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d7avia1, d7avia2
  • Chain 'B':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d7avib1, d7avib2
  • Heterogens: S2Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7aviA (A:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >7aviA (A:)
geeqmrlpsadvyrfaepdseeniifeenmgipiikagtviklierltyhmyadpnfvrt
flttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvq
lrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiardn
tfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtke
dkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvl
evvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgi
yltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffe
nlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7aviB (B:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >7aviB (B:)
geeqmrlpsadvyrfaepdseeniifeenmgipiikagtviklierltyhmyadpnfvrt
flttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvq
lrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiardn
tfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtke
dkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvl
evvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgi
yltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffe
nlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn