PDB entry 7apg

View 7apg on RCSB PDB site
Description: Crystal structure of JAK3 in complex with FM587 (compound 9a)
Class: transferase
Keywords: kinase, JAK3, inhibitor, covalent inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2020-10-16, released 2020-12-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-13, with a file datestamp of 2021-01-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-293)
      • conflict (139)
      • conflict (238)
    Domains in SCOPe 2.08: d7apga_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-293)
      • conflict (139)
      • conflict (238)
    Domains in SCOPe 2.08: d7apgb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (2-293)
      • expression tag (0-1)
      • conflict (139)
      • conflict (230)
      • conflict (238)
    Domains in SCOPe 2.08: d7apgc1, d7apgc2
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-293)
      • conflict (139)
      • conflict (238)
    Domains in SCOPe 2.08: d7apgd_
  • Heterogens: RQT, PHU, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7apgA (A:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >7apgA (A:)
dptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqrei
qilkalhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgm
eylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyape
slsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmalsrllelleegqrlpapp
acpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7apgB (B:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >7apgB (B:)
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgme
ylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapes
lsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmalsrllelleegqrlpappa
cpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7apgC (C:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >7apgC (C:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7apgD (D:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >7apgD (D:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmey
lgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapesl
sdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmalsrllelleegqrlpappac
paevhelmklcwapspqdrpsfsalgpqldmlwsgsr