PDB entry 7apf

View 7apf on RCSB PDB site
Description: Crystal structure of JAK3 in complex with FM601 (compound 10a)
Class: transferase
Keywords: kinase, JAK3, inhibitor, covalent inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2020-10-16, released 2020-12-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-13, with a file datestamp of 2021-01-08.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-293)
      • conflict (139)
      • conflict (230)
      • conflict (238)
    Domains in SCOPe 2.08: d7apfa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-293)
      • conflict (139)
      • conflict (230)
      • conflict (238)
    Domains in SCOPe 2.08: d7apfb_
  • Heterogens: RQZ, PHU, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7apfA (A:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >7apfA (A:)
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqi
ckgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqspifw
yapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllel
leegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7apfB (B:)
smqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >7apfB (B:)
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgme
ylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapes
lsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllelleegq
rlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr