PDB entry 7aot

View 7aot on RCSB PDB site
Description: The Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone
Class: chaperone
Keywords: Fk-506 binding domain, Hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, CHAPERONE
Deposited on 2020-10-15, released 2021-04-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 0.85 Å
R-factor: N/A
AEROSPACI score: 1.06 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Peptidyl-prolyl cis-trans isomerase FKBP5
  Species: Homo sapiens [TaxId:9606]
  Gene: FKBP5, AIG6, FKBP51
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q13451 (3-End)
    • expression tag (0-2)
    • engineered mutation (6)
  Domains in SCOPe 2.08: d7aota1, d7aota2
• Heterogens: RTQ, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >7aotA (A:)
  gapatvteqgeditskkdrgvlkivkrvgngeetpmigdkvyvhykgklsngkkfdsshd
  rnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsagslpkipsnatlffei
  elldfkge
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >7aotA (A:)
  gapatvteqgeditskkdrgvlkivkrvgngeetpmigdkvyvhykgklsngkkfdsshd
  rnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsagslpkipsnatlffei
  elldfkg