PDB entry 7ao8

View 7ao8 on RCSB PDB site
Description: structure of the mta1/hdac1/mbd2 nurd deacetylase complex
Deposited on 2020-10-14, released 2020-11-11
The last revision was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: EM
Resolution: 4.5 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: metastasis-associated protein mta1
    Species: Homo sapiens [TaxId:9606]
    Gene: MTA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: histone deacetylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC1, RPD3L1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Methyl-CpG-binding domain protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MBD2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: metastasis-associated protein mta1
    Species: Homo sapiens [TaxId:9606]
    Gene: MTA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: histone deacetylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC1, RPD3L1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: IHP, ZN, K

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ao8A (A:)
maanmyrvgdyvyfensssnpylirrieelnktangnveakvvcfyrrrdisstlialad
khatlsvcykagpgadngeegeieeemenpemvdlpeklkhqlrhrelflsrqleslpat
hirgkcsvtllneteslksyleredfffyslvydpqqktlladkgeirvgnryqaditdl
lkegeedgrdqsrletqvweahnpltdkqidqflvvarsvgtfaraldcsssvrqpslhm
saaaasrditlfhamdtlhkniydiskaisalvpqggpvlcrdemeewsaseanlfeeal
ekygkdftdiqqdflpwksltsiieyyymwkttdryvqqkrlkaaeaesklkqvyipnyn
kpnpnqisvnnvkagvvngtgapgqspgagracescyttqsyqwyswgppnmqcrlcasc
wtywkkygglkmptrldgerpgpnrsnmsphglparssgspkfamktrqafylhttkltr
iarrlcreilrpwhaarhpylpinsaaikaectarlpeasqsplvlkqavrkpleavlry
lethprppkpdpvksvssvlssltpakvapvinngsptilgkrsyeqhngvdgnmkkrll
mpsrglanhgqarhmgpsrnlllngksyptkvrlirggslppvkrrrmnwidapddvfym
ateetrkirkllsssetkraarrpykpialrqsqalpprppppapvndepivied

    Sequence, based on observed residues (ATOM records):
    >7ao8A (A:)
gdyvyfensssnpylirrieelnktangnveakvvcfyrrrdishqlrhrelflsrqles
lpathirgkcsvtllneteslksyleredfffyslvydpqqktladgeirvgnryqadit
dllkegeedgrdqsrletqvweahnpltdkqidqflvvarsvgtfaraldslhmsaaaas
rditlfhamdtlhkniydiskaisalvpqggpvlcrdemeewsaseanlfeealekygkd
ftdiqqdflpwksltsiieyyymwkttdryvqqk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ao8B (B:)
maqtqgtrrkvcyyydgdvgnyyygqghpmkphrirmthnlllnyglyrkmeiyrphkan
aeemtkyhsddyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvas
avklnkqqtdiavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhg
dgveeafyttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnyplrdgiddesyeai
fkpvmskvmemfqpsavvlqcgsdslsgdrlgcfnltikghakcvefvksfnlpmlmlgg
ggytirnvarcwtyetavaldteipnelpyndyfeyfgpdfklhispsnmtnqntneyle
kikqrlfenlrmlphapgvqmqaipedaipeesgdededdpdkrisicssdkriaceeef
sdseeegeggrknssnfkkakrvktedekekdpeekkevteeektkeekpeakgvkeevk
la

    Sequence, based on observed residues (ATOM records):
    >7ao8B (B:)
rrkvcyyydgdvgnyyygqghpmkphrirmthnlllnyglyrkmeiyrphkanaeemtky
hsddyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvasavklnkq
qtdiavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveeaf
yttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnyplrdgiddesyeaifkpvmsk
vmemfqpsavvlqcgsdslsgdrlgcfnltikghakcvefvksfnlpmlmlggggytirn
varcwtyetavaldteipnelpyndyfeyfgpdfklhispsnmtnqntneylekikqrlf
enlrmlpha

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7ao8C (C:)
mrahpgggrccpeqeegesaaggsgaggdsaieqggqgsalapspvsgvrregargggrg
rgrwkqagrgggvcgrgrgrgrgrgrgrgrgrgrgrppsggsglggdgggcggggsgggg
aprrepvpfpsgsagpgprgpratesgkrmdcpalppgwkkeevirksglsagksdvyyf
spsgkkfrskpqlarylgntvdlssfdfrtgkmmpsklqknkqrlrndplnqnkgkpdln
ttlpirqtasifkqpvtkvtnhpsnkvksdpqrmneqprqlfwekrlqglsasdvteqii
ktmelpkglqgvgpgsndetllsavasalhtssapitgqvsaaveknpavwlntsqplck
afivtdedirkqeervqqvrkkleealmadilsraadteemdiemdsgdea

    Sequence, based on observed residues (ATOM records):
    >7ao8C (C:)
rmdcpalppgwkkeevirksglsagksdvyyfspsgkkfrskpqlarylgntvdlssfdf
rtgk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7ao8D (D:)
maanmyrvgdyvyfensssnpylirrieelnktangnveakvvcfyrrrdisstlialad
khatlsvcykagpgadngeegeieeemenpemvdlpeklkhqlrhrelflsrqleslpat
hirgkcsvtllneteslksyleredfffyslvydpqqktlladkgeirvgnryqaditdl
lkegeedgrdqsrletqvweahnpltdkqidqflvvarsvgtfaraldcsssvrqpslhm
saaaasrditlfhamdtlhkniydiskaisalvpqggpvlcrdemeewsaseanlfeeal
ekygkdftdiqqdflpwksltsiieyyymwkttdryvqqkrlkaaeaesklkqvyipnyn
kpnpnqisvnnvkagvvngtgapgqspgagracescyttqsyqwyswgppnmqcrlcasc
wtywkkygglkmptrldgerpgpnrsnmsphglparssgspkfamktrqafylhttkltr
iarrlcreilrpwhaarhpylpinsaaikaectarlpeasqsplvlkqavrkpleavlry
lethprppkpdpvksvssvlssltpakvapvinngsptilgkrsyeqhngvdgnmkkrll
mpsrglanhgqarhmgpsrnlllngksyptkvrlirggslppvkrrrmnwidapddvfym
ateetrkirkllsssetkraarrpykpialrqsqalpprppppapvndepivied

    Sequence, based on observed residues (ATOM records):
    >7ao8D (D:)
gdyvyfensssnpylirrieelnktangnveakvvcfyrrrdishqlrhrelflsrqles
lpathirgkcsvtllneteslksyleredfffyslvydpqqktladgeirvgnryqadit
dllkegeedgrdqsrletqvweahnpltdkqidqflvvarsvgtfaraldslhmsaaaas
rditlfhamdtlhkniydiskaisalvpqggpvlcrdemeewsaseanlfeealekygkd
ftdiqqdflpwksltsiieyyymwkttdryvqqk

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7ao8E (E:)
maqtqgtrrkvcyyydgdvgnyyygqghpmkphrirmthnlllnyglyrkmeiyrphkan
aeemtkyhsddyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvas
avklnkqqtdiavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhg
dgveeafyttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnyplrdgiddesyeai
fkpvmskvmemfqpsavvlqcgsdslsgdrlgcfnltikghakcvefvksfnlpmlmlgg
ggytirnvarcwtyetavaldteipnelpyndyfeyfgpdfklhispsnmtnqntneyle
kikqrlfenlrmlphapgvqmqaipedaipeesgdededdpdkrisicssdkriaceeef
sdseeegeggrknssnfkkakrvktedekekdpeekkevteeektkeekpeakgvkeevk
la

    Sequence, based on observed residues (ATOM records):
    >7ao8E (E:)
rrkvcyyydgdvgnyyygqghpmkphrirmthnlllnyglyrkmeiyrphkanaeemtky
hsddyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvasavklnkq
qtdiavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveeaf
yttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnyplrdgiddesyeaifkpvmsk
vmemfqpsavvlqcgsdslsgdrlgcfnltikghakcvefvksfnlpmlmlggggytirn
varcwtyetavaldteipnelpyndyfeyfgpdfklhispsnmtnqntneylekikqrlf
enlrmlpha