PDB entry 7akl

View 7akl on RCSB PDB site
Description: Structure of DYRK1A in complex with compound 50
Class: transferase
Keywords: serine/threonine-protein kinase, phosphoprotein, kinase selectivity, transferase, sbdd, small molecule inhibitor
Deposited on 2020-10-01, released 2021-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7akla_
  • Heterogens: RK5, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7aklA (A:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktade

    Sequence, based on observed residues (ATOM records): (download) 
    >7aklA (A:)
ivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqaqievrll
elmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvslnltrkfaq
qmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyqyiqsrfy
rspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgippahildq
apkarkffeklpdgtwnlkktkdykppgtrklhnilgvetggpggrragesghtvadylk
fkdlilrmldydpktriqpyyalqhsffkk