PDB entry 7ajs

View 7ajs on RCSB PDB site
Description: Structure of DYRK1A in complex with compound 33
Class: transferase
Keywords: serine/threonine-protein kinase, phosphoprotein, kinase selectivity, transferase, sbdd, small molecule inhibitor
Deposited on 2020-09-29, released 2021-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (21-352)
      • expression tag (14-20)
      • expression tag (353)
    Domains in SCOPe 2.08: d7ajsa1, d7ajsa2, d7ajsa3
  • Chain 'B':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (21-352)
      • expression tag (15-20)
      • expression tag (353)
    Domains in SCOPe 2.08: d7ajsb1, d7ajsb2, d7ajsb3
  • Heterogens: RKH, GOL, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ajsA (A:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffaa

    Sequence, based on observed residues (ATOM records): (download) 
    >7ajsA (A:)
vprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqa
qievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvsln
ltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyq
yiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgip
pahildqapkarkffeklpdgtwnlkktkdeykppgtrklhnilgvetggpggrragesg
htvadylkfkdlilrmldydpktriqpyyalqhsffa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ajsB (B:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffaa

    Sequence, based on observed residues (ATOM records): (download) 
    >7ajsB (B:)
prgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqaq
ievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvslnl
trkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyqy
iqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgipp
ahildqapkarkffeklpdgtwnlkkeykppgtrklhnilgvetggpggrragesghtva
dylkfkdlilrmldydpktriqpyyalqhsffa