PDB entry 7aj2

View 7aj2 on RCSB PDB site
Description: Structure of DYRK1A in complex with compound 3
Class: transferase
Keywords: serine/threonine-protein kinase, phosphoprotein, kinase selectivity, transferase, sbdd, small molecule inhibitor
Deposited on 2020-09-28, released 2021-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7aj2a_
  • Heterogens: RJ5, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7aj2A (A:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktade

    Sequence, based on observed residues (ATOM records): (download) 
    >7aj2A (A:)
ivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqaqievrll
elmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvslnltrkfaq
qmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyqyiqsrfy
rspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgippahildq
apkarkffeklpdgtwnlkktkdykppgtrklhnilgvetggpggrragesghtvadylk
fkdlilrmldydpktriqpyyalqhsffkk