PDB entry 7aio

View 7aio on RCSB PDB site
Description: structure of human potassium chloride transporter kcc3 s45d/t940d/t997d in nacl (subclass)
Deposited on 2020-09-28, released 2021-06-02
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: EM
Resolution: 3.31 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Solute carrier family 12 member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC12A6, KCC3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UHW9 (0-1098)
      • engineered mutation (44)
      • engineered mutation (939)
      • engineered mutation (996)
  • Chain 'B':
    Compound: Solute carrier family 12 member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC12A6, KCC3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UHW9 (0-1098)
      • engineered mutation (44)
      • engineered mutation (939)
      • engineered mutation (996)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7aioA (A:)
mphftvtkvedpeegaaasisqepsladikariqdsdepdlsqnditgehsqllddghkk
arnaylnnsnyeegdeyfdknlalfeeemdtrpkvssllnrmanytnltqgakeheeaen
itegkkkptktpqmgtfmgvylpclqnifgvilflrltwvvgtagvlqafaivlicccct
mltaismsaiatngvvpaggsyfmisralgpefggavglcfylgttfaaamyilgaieif
lvyivpraaifhsddalkesaamlnnmrvygtaflvlmvlvvfigvryvnkfaslflacv
ivsilaiyagaikssfapphfpvcmlgnrtlssrhidvcsktkeinnmtvpsklwgffcn
ssqffnatcdeyfvhnnvtsiqgipglasgiitenlwsnylpkgeiiekpsakssdvlgs
lnheyvlvdittsftllvgiffpsvtgimagsnrsgdlkdaqksipigtilailttsfvy
lsnvvlfgaciegvvlrdkfgdavkgnlvvgtlswpspwvivigsffstcgaglqsltga
prllqaiakdniipflrvfghskangeptwallltaaiaelgiliasldlvapilsmffl
mcylfvnlacalqtllrtpnwrprfryyhwalsfmgmsiclalmfisswyyaivamviag
miykyieyqgaekewgdgirglslsaarfallrleegpphtknwrpqllvllkldedlhv
khprlltfasqlkagkgltivgsvivgnflenygealaaeqtikhlmeaekvkgfcqlvv
aaklregishliqscglggmkhntvvmgwpngwrqsedarawktfigtvrvttaahlall
vaknisffpsnveqfsegnidvwwivhdggmlmllpfllkqhkvwrkcsiriftvaqled
nsiqmkkdlatflyhlrieaevevvemhdsdisaytyerdlmmeqrsqmlrhmrlskter
dreaqlvkdrnsmlrltsigsdedeetetyqekvhmdwtkdkymasrgqkaksmegfqdl
lnmrpdqsnvrrmhtavklnevivnksheaklvllnmpgpprnpegdenymeflevlteg
lervllvrgggsevitiys

    Sequence, based on observed residues (ATOM records):
    >7aioA (A:)
manytnltqgakeheeaenitekkptktpqmgtfmgvylpclqnifgvilflrltwvvgt
agvlqafaivlicccctmltaismsaiatngvvpaggsyfmisralgpefggavglcfyl
gttfaaamyilgaieiflvyivpraaifhsddalkesaamlnnmrvygtaflvlmvlvvf
igvryvnkfaslflacvivsilaiyagaikssfapphfpvcmlgnrtlssrhidvcsktk
einnmtvpsklwgffcnssqffnatcdeyfvhnnvtsiqgipglasgiitenlwsnylpk
geiiekpsakssdvlgslnheyvlvdittsftllvgiffpsvtgimagsnrsgdlkdaqk
sipigtilailttsfvylsnvvlfgaciegvvlrdkfgdavkgnlvvgtlswpspwvivi
gsffstcgaglqsltgaprllqaiakdniipflrvfghskangeptwallltaaiaelgi
liasldlvapilsmfflmcylfvnlacalqtllrtpnwrprfryyhwalsfmgmsiclal
mfisswyyaivamviagmiykyieyqgaekewgdgirglslsaarfallrleegpphtkn
wrpqllvllkldedlhvkhprlltfasqlkagkgltivgsvivgnflenygealaaeqti
khlmeaekvkgfcqlvvaaklregishliqscglggmkhntvvmgwpngwrqsedarawk
tfigtvrvttaahlallvaknisffpsnveqfsegnidvwwivhdggmlmllpfllkqhk
vwrkcsiriftvansiqmkkdlatflyhlrieaevevvemhdsdisaytyerdlmmeqrs
qmsnvrrmhtavklnevivnksheaklvllnmpgpprnpegdenymeflevlteglervl
lvrgggsev

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7aioB (B:)
mphftvtkvedpeegaaasisqepsladikariqdsdepdlsqnditgehsqllddghkk
arnaylnnsnyeegdeyfdknlalfeeemdtrpkvssllnrmanytnltqgakeheeaen
itegkkkptktpqmgtfmgvylpclqnifgvilflrltwvvgtagvlqafaivlicccct
mltaismsaiatngvvpaggsyfmisralgpefggavglcfylgttfaaamyilgaieif
lvyivpraaifhsddalkesaamlnnmrvygtaflvlmvlvvfigvryvnkfaslflacv
ivsilaiyagaikssfapphfpvcmlgnrtlssrhidvcsktkeinnmtvpsklwgffcn
ssqffnatcdeyfvhnnvtsiqgipglasgiitenlwsnylpkgeiiekpsakssdvlgs
lnheyvlvdittsftllvgiffpsvtgimagsnrsgdlkdaqksipigtilailttsfvy
lsnvvlfgaciegvvlrdkfgdavkgnlvvgtlswpspwvivigsffstcgaglqsltga
prllqaiakdniipflrvfghskangeptwallltaaiaelgiliasldlvapilsmffl
mcylfvnlacalqtllrtpnwrprfryyhwalsfmgmsiclalmfisswyyaivamviag
miykyieyqgaekewgdgirglslsaarfallrleegpphtknwrpqllvllkldedlhv
khprlltfasqlkagkgltivgsvivgnflenygealaaeqtikhlmeaekvkgfcqlvv
aaklregishliqscglggmkhntvvmgwpngwrqsedarawktfigtvrvttaahlall
vaknisffpsnveqfsegnidvwwivhdggmlmllpfllkqhkvwrkcsiriftvaqled
nsiqmkkdlatflyhlrieaevevvemhdsdisaytyerdlmmeqrsqmlrhmrlskter
dreaqlvkdrnsmlrltsigsdedeetetyqekvhmdwtkdkymasrgqkaksmegfqdl
lnmrpdqsnvrrmhtavklnevivnksheaklvllnmpgpprnpegdenymeflevlteg
lervllvrgggsevitiys

    Sequence, based on observed residues (ATOM records):
    >7aioB (B:)
manytnltqgakeheeaenitekkptktpqmgtfmgvylpclqnifgvilflrltwvvgt
agvlqafaivlicccctmltaismsaiatngvvpaggsyfmisralgpefggavglcfyl
gttfaaamyilgaieiflvyivpraaifhsddalkesaamlnnmrvygtaflvlmvlvvf
igvryvnkfaslflacvivsilaiyagaikssfapphfpvcmlgnrtlssrhidvcsktk
einnmtvpsklwgffcnssqffnatcdeyfvhnnvtsiqgipglasgiitenlwsnylpk
geiiekpsakssdvlgslnheyvlvdittsftllvgiffpsvtgimagsnrsgdlkdaqk
sipigtilailttsfvylsnvvlfgaciegvvlrdkfgdavkgnlvvgtlswpspwvivi
gsffstcgaglqsltgaprllqaiakdniipflrvfghskangeptwallltaaiaelgi
liasldlvapilsmfflmcylfvnlacalqtllrtpnwrprfryyhwalsfmgmsiclal
mfisswyyaivamviagmiykyieyqgaekewgdgirglslsaarfallrleegpphtkn
wrpqllvllkldedlhvkhprlltfasqlkagkgltivgsvivgnflenygealaaeqti
khlmeaekvkgfcqlvvaaklregishliqscglggmkhntvvmgwpngwrqsedarawk
tfigtvrvttaahlallvaknisffpsnveqfsegnidvwwivhdggmlmllpfllkqhk
vwrkcsiriftvaqlednsiqmkkdlatflyhlrieaevevvemhdsdisaytyerdlmm
eqrsnvrrmhtavklnevivnksheaklvllnmpgpprnpegdenymeflevlteglerv
llvrgggsev