PDB entry 7ad7

View 7ad7 on RCSB PDB site
Description: crystal structure of human complement c5 in complex with the k8 bovine knob domain peptide.
Deposited on 2020-09-14, released 2021-03-10
The last revision was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Gene: C5, CPAMD4
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Gene: C5, CPAMD4
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: K8 peptide
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • PDB 7AD7 (0-51)
  • Heterogens: NAG, MPD, MHA, EOH, CYS, TAM, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ad7A (A:)
mgllgilcfliflgktwgqeqtyvisapkifrvgaseniviqvygyteafdatisiksyp
dkkfsyssghvhlssenkfqnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpit
ydngflfihtdkpvytpdqsvkvrvyslnddlkpakretvltfidpegsevdmveeidhi
giisfpdfkipsnprygmwtikakykedfsttgtayfevkeyvlphfsvsiepeynfigy
knfknfeitikaryfynkvvteadvyitfgiredlkddqkemmqtamqntmlingiaqvt
fdsetavkelsyysledlnnkylyiavtviestggfseeaeipgikyvlspyklnlvatp
lflkpgipypikvqvkdsldqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasf
vlnlpsgvtvlefnvktdapdlpeenqaregyraiaysslsqsylyidwtdnhkallvge
hlniivtpkspyidkithynylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrl
lvyyivtgeqtaelvsdsvwlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswv
alaavdsavygvqrgakkplervfqfleksdlgcgaggglnnanvfhlagltfltnanad
dsqendepckeilrprrtlqkkieeiaakykhsvvkkccydgacvnndetceqraarisl
gprcikafteccvvasqlranishkdmqlgrlhmktllpvskpeirsyfpeswlwevhlv
prrkqlqfalpdslttweiqgvgisntgicvadtvkakvfkdvflemnipysvvrgeqiq
lkgtvynyrtsgmqfcvkmsavegictsespvidhqgtksskcvrqkvegssshlvtftv
lpleiglhninfsletwfgkeilvktlrvvpegvkresysgvtldprgiygtisrrkefp
yripldlvpkteikrilsvkgllvgeilsavlsqeginilthlpkgsaeaelmsvvpvfy
vfhyletgnhwnifhsdpliekqklkkklkegmlsimsyrnadysysvwkggsastwlta
falrvlgqvnkyveqnqnsicnsllwlvenyqldngsfkensqyqpiklqgtlpvearen
slyltaftvigirkafdicplvkidtalikadnfllentlpaqstftlaisayalslgdk
thpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssvpntgtarmvettayalltsln
lkdinyvnpvikwlseeqrygggfystqdtinaieglteysllvkqlrlsmdidvsykhk
galhnykmtdknflgrpvevllnddlivstgfgsglatvhvttvvhktstseevcsfylk
idtqdieashyrgygnsdykrivacasykpsreesssgsshavmdislptgisaneedlk
alvegvdqlftdyqikdghvilqlnsipssdflcvrfrifelfevgflspatftvyeyhr
pdkqctmfystsnikiqkvcegaackcveadcgqmqeeldltisaetrkqtackpeiaya
ykvsitsitvenvfvkykatlldiyktgeavaekdseitfikkvtctnaelvkgrqylim
gkealqikynfsfryiypldsltwieywprdttcsscqaflanldefaediflngc

    Sequence, based on observed residues (ATOM records):
    >7ad7A (A:)
ieeiaakykhsvvkkccydgacvnndetceqraarislgprcikafteccvvasqlrakp
eirsyfpeswlwevhlvprrkqlqfalpdslttweiqgvgisntgicvadtvkakvfkdv
flemnipysvvrgeqiqlkgtvynyrtsgmqfcvkmsavegictkcvrqkvegssshlvt
ftvlpleiglhninfsletwfgkeilvktlrvvpegvkresysgvtldprgiygtisrrk
efpyripldlvpkteikrilsvkgllvgeilsavlsqilthlpkgsaeaelmsvvpvfyv
fhyletgnhwnifhsdpliekqklkkklkegmlsimsyrnadysysvwkggsastwltaf
alrvlgqvnkyveqnqnsicnsllwlvenyqldngsfkensqyqpiklqgtlpvearens
lyltaftvigirkafdicplvkidtalikadnfllentlpaqstftlaisayalslgdkt
hpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssvpntgtarmvettayalltslnl
kdinyvnpvikwlseeqrygggfystqdtinaieglteysllvkqlrlsmdidvsykhkg
alhnykmtdknflgrpvevllnddlivstgfgsglatvhvttvvhktstseevcsfylki
dtqdiedykrivacasykpsreesssgsshavmdislptgisaneedlkalvegvdqlft
dyqikdghvilqlnsipssdflcvrfrifelfevgflspatftvyeyhrpdkqctmfyst
sn

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ad7B (B:)
mgllgilcfliflgktwgqeqtyvisapkifrvgaseniviqvygyteafdatisiksyp
dkkfsyssghvhlssenkfqnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpit
ydngflfihtdkpvytpdqsvkvrvyslnddlkpakretvltfidpegsevdmveeidhi
giisfpdfkipsnprygmwtikakykedfsttgtayfevkeyvlphfsvsiepeynfigy
knfknfeitikaryfynkvvteadvyitfgiredlkddqkemmqtamqntmlingiaqvt
fdsetavkelsyysledlnnkylyiavtviestggfseeaeipgikyvlspyklnlvatp
lflkpgipypikvqvkdsldqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasf
vlnlpsgvtvlefnvktdapdlpeenqaregyraiaysslsqsylyidwtdnhkallvge
hlniivtpkspyidkithynylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrl
lvyyivtgeqtaelvsdsvwlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswv
alaavdsavygvqrgakkplervfqfleksdlgcgaggglnnanvfhlagltfltnanad
dsqendepckeilrprrtlqkkieeiaakykhsvvkkccydgacvnndetceqraarisl
gprcikafteccvvasqlranishkdmqlgrlhmktllpvskpeirsyfpeswlwevhlv
prrkqlqfalpdslttweiqgvgisntgicvadtvkakvfkdvflemnipysvvrgeqiq
lkgtvynyrtsgmqfcvkmsavegictsespvidhqgtksskcvrqkvegssshlvtftv
lpleiglhninfsletwfgkeilvktlrvvpegvkresysgvtldprgiygtisrrkefp
yripldlvpkteikrilsvkgllvgeilsavlsqeginilthlpkgsaeaelmsvvpvfy
vfhyletgnhwnifhsdpliekqklkkklkegmlsimsyrnadysysvwkggsastwlta
falrvlgqvnkyveqnqnsicnsllwlvenyqldngsfkensqyqpiklqgtlpvearen
slyltaftvigirkafdicplvkidtalikadnfllentlpaqstftlaisayalslgdk
thpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssvpntgtarmvettayalltsln
lkdinyvnpvikwlseeqrygggfystqdtinaieglteysllvkqlrlsmdidvsykhk
galhnykmtdknflgrpvevllnddlivstgfgsglatvhvttvvhktstseevcsfylk
idtqdieashyrgygnsdykrivacasykpsreesssgsshavmdislptgisaneedlk
alvegvdqlftdyqikdghvilqlnsipssdflcvrfrifelfevgflspatftvyeyhr
pdkqctmfystsnikiqkvcegaackcveadcgqmqeeldltisaetrkqtackpeiaya
ykvsitsitvenvfvkykatlldiyktgeavaekdseitfikkvtctnaelvkgrqylim
gkealqikynfsfryiypldsltwieywprdttcsscqaflanldefaediflngc

    Sequence, based on observed residues (ATOM records):
    >7ad7B (B:)
eqtyvisapkifrvgaseniviqvygyteafdatisiksypdkkfsyssghvhlssenkf
qnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpitydngflfihtdkpvytpdq
svkvrvyslnddlkpakretvltfidpegsevdmveeidhigiisfpdfkipsnprygmw
tikakykedfsttgtayfevkeyvlphfsvsiepeynfigyknfknfeitikaryfynkv
vteadvyitfgiredlkddqkemmqtamqntmlingiaqvtfdsetavkelsyysledln
nkylyiavtviestggfseeaeipgikyvlspyklnlvatplflkpgipypikvqvkdsl
dqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasfvlnlpsgvtvlefnvktda
pdlpeenqaregyraiaysslsqsylyidwtdnhkallvgehlniivtpkspyidkithy
nylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrllvyyivtgeqtaelvsdsv
wlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswvalaavdsavygfqfleksd
lgcgaggglnnanvfhlagltfltnanaddsqcke

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >7ad7C (C:)
svcpdgfdwgygcaagssrfctrhdwccyderadshtygfctgnrvenlyfq