PDB entry 7acd

View 7acd on RCSB PDB site
Description: crystal structure of the human mettl3-mettl14 complex with compound t30 (uzh1a)
Deposited on 2020-09-10, released 2020-10-28
The last revision was dated 2021-10-13, with a file datestamp of 2021-10-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: N6-adenosine-methyltransferase catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: METTL3, MTA70
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q86U44 (19-245)
      • initiating methionine (0)
      • expression tag (1-18)
  • Chain 'B':
    Compound: N6-adenosine-methyltransferase non-catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: METTL14, KIAA1627
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HCE5 (1-289)
      • initiating methionine (0)
  • Heterogens: R72, MG, ACT, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7acdA (A:)
mghhhhhhssgrenlyfqgaltqsvggdssadrlfppqwiccdiryldvsilgkfavvma
dppwdihmelpygtltddemrrlnipvlqddgflflwvtgramelgreclnlwgyervde
iiwvktnqlqriirtgrtghwlnhgkehclvgvkgnpqgfnqgldcdvivaevrstshkp
deiygmierlspgtrkielfgrphnvqpnwitlgnqldgihlldpdvvarfkqrypdgii
skpknl

    Sequence, based on observed residues (ATOM records):
    >7acdA (A:)
lfppqwiccdiryldvsilgkfavvmadppwdihelpygtltddemrrlnipvlqddgfl
flwvtgramelgreclnlwgyervdeiiwvktnqlqriihwlnhgkehclvgvkgnpqgf
nqgldcdvivaevrstshkpdeiygmierlspgtrkielfgrphnvqpnwitlgnqldgi
hlldpdvvarfkqrypdgiisk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7acdB (B:)
mlkgtqslnphndycqhfvdtghrpqnfirdvgladrfeeypklrelirlkdeliaksnt
ppmylqadieafdireltpkfdvilleppleeyyretgitanekcwtwddimkleideia
aprsfiflwcgsgegldlgrvclrkwgyrrcedicwiktnknnpgktktldpkavfqrtk
ehclmgikgtvkrstdgdfihanvdidliiteepeigniekpveifhiiehfclgrrrlh
lfgrdstirpgwltvgptltnsnynaetyasyfsapnsyltgcteeierl

    Sequence, based on observed residues (ATOM records):
    >7acdB (B:)
ndycqhfvdtghrpqnfirdrelirlkdeliaksntppmylqadieafdireltpkfdvi
lleppleeyyrkcwtwddimkleideiaaprsfiflwcgsgegldlgrvclrkwgyrrce
dicwiktnknnpldpkavfqrtkehclmgikgtvdidliiteepeigniekpveifhiie
hfclgrrrlhlfgrdstirpgwltvgptltnsnynaetyasyfsapnsyltgctee