PDB entry 7abe

View 7abe on RCSB PDB site
Description: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-769
Class: hydrolase
Keywords: Phosphodiesterase, hydrolase, cAMP hydrolysis, alternative splicing
Deposited on 2020-09-07, released 2021-10-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-10-06, with a file datestamp of 2021-10-01.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08499 (4-363)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7abea_
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08499 (4-363)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7abeb_
  • Chain 'C':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08499 (4-363)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7abec_
  • Chain 'D':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08499 (4-363)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7abed_
  • Heterogens: J2E, ZN, MG, EDO, EPE, DMS, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7abeA (A:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records): (download) 
    >7abeA (A:)
fgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdt
litylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihd
vdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslr
kmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsn
ptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplw
etwadlvhpdaqdildtlednrewyqstip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7abeB (B:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records): (download) 
    >7abeB (B:)
edvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylmt
ledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgvs
nqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidiv
latdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkplql
yrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadlv
hpdaqdildtlednrewyqstipq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7abeC (C:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records): (download) 
    >7abeC (C:)
teqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlity
lmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhp
gvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvi
divlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkp
lqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwa
dlvhpdaqdildtlednrewyqstip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7abeD (D:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records): (download) 
    >7abeD (D:)
qedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylm
tledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgv
snqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidi
vlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkplq
lyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadl
vhpdaqdildtlednrewyqstip