PDB entry 7a6u

View 7a6u on RCSB PDB site
Description: cryo-em structure of the cytoplasmic domain of human trpc6
Deposited on 2020-08-26, released 2020-09-30
The last revision was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: EM
Resolution: 3.62 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y210 (0-930)
      • expression tag (931-956)
  • Chain 'B':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y210 (0-930)
      • expression tag (931-956)
  • Chain 'C':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y210 (0-930)
      • expression tag (931-956)
  • Chain 'D':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y210 (0-930)
      • expression tag (931-956)
  • Heterogens: UNX

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7a6uA (A:)
msqspafgprrgssprgaagaaarrnesqdyllmdselgedgcpqaplpcygyypcfrgs
dnrlahrrqtvlrekgrrlanrgpaymfsdrstslsieeerfldaaeygnipvvrkmlee
chslnvncvdymgqnalqlavanehleitelllkkenlsrvgdalllaiskgyvriveai
lshpafaegkrlatspsqselqqddfyaydedgtrfshdvtpiilaahcqeyeivhtllr
kgarierphdyfckcndcnqkqkhdsfshsrsrinaykglaspaylslssedpvmtalel
snelavlaniekefkndykklsmqckdfvvglldlcrnteeveailngdvetlqsgdhgr
pnlsrlklaikyevkkfvahpncqqqllsiwyenlsglrqqtmavkflvvlavaiglpfl
aliywfapcskmgkimrgpfmkfvahaasftiflgllvmnaadrfegtkllpnetstdna
kqlfrmktscfswmemliiswvigmiwaeckeiwtqgpkeylfelwnmldfgmlaifaas
fiarfmafwhaskaqsiidandtlkdltkvtlgdnvkyynlarikwdpsdpqiiseglya
iavvlsfsriayilpanesfgplqislgrtvkdifkfmvifimvfvafmigmfnlysyyi
gakqneafttveesfktlfwaifglsevksvvinynhkfienigyvlygvynvtmvivll
nmliaminssfqeieddadvewkfaraklwfsyfeegrtlpvpfnlvpspkslfylllkl
kkwiselfqghkkgfqedaemnkineekklgilgshedlsklsldkkqvghnkqpsirss
edfhlnsfnnpprqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelle
eksqntedlaelirelgeklsmepnqeetnraenlyfqshhhhhhhhhhdykddddk

    Sequence, based on observed residues (ATOM records):
    >7a6uA (A:)
ymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavaneh
leitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqdd
fyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhd
sfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqc
kdfvvglldlcrnteeveailngdrqyqkimkrlikryvlqaqidkesdevnegelkeik
qdisslryelleeksqntedlaelirelgekl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7a6uB (B:)
msqspafgprrgssprgaagaaarrnesqdyllmdselgedgcpqaplpcygyypcfrgs
dnrlahrrqtvlrekgrrlanrgpaymfsdrstslsieeerfldaaeygnipvvrkmlee
chslnvncvdymgqnalqlavanehleitelllkkenlsrvgdalllaiskgyvriveai
lshpafaegkrlatspsqselqqddfyaydedgtrfshdvtpiilaahcqeyeivhtllr
kgarierphdyfckcndcnqkqkhdsfshsrsrinaykglaspaylslssedpvmtalel
snelavlaniekefkndykklsmqckdfvvglldlcrnteeveailngdvetlqsgdhgr
pnlsrlklaikyevkkfvahpncqqqllsiwyenlsglrqqtmavkflvvlavaiglpfl
aliywfapcskmgkimrgpfmkfvahaasftiflgllvmnaadrfegtkllpnetstdna
kqlfrmktscfswmemliiswvigmiwaeckeiwtqgpkeylfelwnmldfgmlaifaas
fiarfmafwhaskaqsiidandtlkdltkvtlgdnvkyynlarikwdpsdpqiiseglya
iavvlsfsriayilpanesfgplqislgrtvkdifkfmvifimvfvafmigmfnlysyyi
gakqneafttveesfktlfwaifglsevksvvinynhkfienigyvlygvynvtmvivll
nmliaminssfqeieddadvewkfaraklwfsyfeegrtlpvpfnlvpspkslfylllkl
kkwiselfqghkkgfqedaemnkineekklgilgshedlsklsldkkqvghnkqpsirss
edfhlnsfnnpprqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelle
eksqntedlaelirelgeklsmepnqeetnraenlyfqshhhhhhhhhhdykddddk

    Sequence, based on observed residues (ATOM records):
    >7a6uB (B:)
ymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavaneh
leitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqdd
fyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhd
sfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqc
kdfvvglldlcrnteeveailngdrqyqkimkrlikryvlqaqidkesdevnegelkeik
qdisslryelleeksqntedlaelirelgekl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7a6uC (C:)
msqspafgprrgssprgaagaaarrnesqdyllmdselgedgcpqaplpcygyypcfrgs
dnrlahrrqtvlrekgrrlanrgpaymfsdrstslsieeerfldaaeygnipvvrkmlee
chslnvncvdymgqnalqlavanehleitelllkkenlsrvgdalllaiskgyvriveai
lshpafaegkrlatspsqselqqddfyaydedgtrfshdvtpiilaahcqeyeivhtllr
kgarierphdyfckcndcnqkqkhdsfshsrsrinaykglaspaylslssedpvmtalel
snelavlaniekefkndykklsmqckdfvvglldlcrnteeveailngdvetlqsgdhgr
pnlsrlklaikyevkkfvahpncqqqllsiwyenlsglrqqtmavkflvvlavaiglpfl
aliywfapcskmgkimrgpfmkfvahaasftiflgllvmnaadrfegtkllpnetstdna
kqlfrmktscfswmemliiswvigmiwaeckeiwtqgpkeylfelwnmldfgmlaifaas
fiarfmafwhaskaqsiidandtlkdltkvtlgdnvkyynlarikwdpsdpqiiseglya
iavvlsfsriayilpanesfgplqislgrtvkdifkfmvifimvfvafmigmfnlysyyi
gakqneafttveesfktlfwaifglsevksvvinynhkfienigyvlygvynvtmvivll
nmliaminssfqeieddadvewkfaraklwfsyfeegrtlpvpfnlvpspkslfylllkl
kkwiselfqghkkgfqedaemnkineekklgilgshedlsklsldkkqvghnkqpsirss
edfhlnsfnnpprqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelle
eksqntedlaelirelgeklsmepnqeetnraenlyfqshhhhhhhhhhdykddddk

    Sequence, based on observed residues (ATOM records):
    >7a6uC (C:)
ymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavaneh
leitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqdd
fyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhd
sfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqc
kdfvvglldlcrnteeveailngdrqyqkimkrlikryvlqaqidkesdevnegelkeik
qdisslryelleeksqntedlaelirelgekl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7a6uD (D:)
msqspafgprrgssprgaagaaarrnesqdyllmdselgedgcpqaplpcygyypcfrgs
dnrlahrrqtvlrekgrrlanrgpaymfsdrstslsieeerfldaaeygnipvvrkmlee
chslnvncvdymgqnalqlavanehleitelllkkenlsrvgdalllaiskgyvriveai
lshpafaegkrlatspsqselqqddfyaydedgtrfshdvtpiilaahcqeyeivhtllr
kgarierphdyfckcndcnqkqkhdsfshsrsrinaykglaspaylslssedpvmtalel
snelavlaniekefkndykklsmqckdfvvglldlcrnteeveailngdvetlqsgdhgr
pnlsrlklaikyevkkfvahpncqqqllsiwyenlsglrqqtmavkflvvlavaiglpfl
aliywfapcskmgkimrgpfmkfvahaasftiflgllvmnaadrfegtkllpnetstdna
kqlfrmktscfswmemliiswvigmiwaeckeiwtqgpkeylfelwnmldfgmlaifaas
fiarfmafwhaskaqsiidandtlkdltkvtlgdnvkyynlarikwdpsdpqiiseglya
iavvlsfsriayilpanesfgplqislgrtvkdifkfmvifimvfvafmigmfnlysyyi
gakqneafttveesfktlfwaifglsevksvvinynhkfienigyvlygvynvtmvivll
nmliaminssfqeieddadvewkfaraklwfsyfeegrtlpvpfnlvpspkslfylllkl
kkwiselfqghkkgfqedaemnkineekklgilgshedlsklsldkkqvghnkqpsirss
edfhlnsfnnpprqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelle
eksqntedlaelirelgeklsmepnqeetnraenlyfqshhhhhhhhhhdykddddk

    Sequence, based on observed residues (ATOM records):
    >7a6uD (D:)
ymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavaneh
leitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqdd
fyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhd
sfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqc
kdfvvglldlcrnteeveailngdrqyqkimkrlikryvlqaqidkesdevnegelkeik
qdisslryelleeksqntedlaelirelgekl