PDB entry 7a6f

View 7a6f on RCSB PDB site
Description: nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
Deposited on 2020-08-25, released 2020-10-14
The last revision was dated 2020-10-28, with a file datestamp of 2020-10-23.
Experiment type: EM
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multidrug resistance protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCB1, MDR1, PGY1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08183
      • variant (892)
  • Chain 'B':
    Compound: MRK16 Fab-fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7A6F (0-218)
  • Chain 'C':
    Compound: MRK16 Fab-fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7A6F (0-217)
  • Heterogens: ZQU, CLR

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7a6fA (A:)
mdlegdrnggakkknffklnnksekdkkekkptvsvfsmfrysnwldklymvvgtlaaii
hgaglplmmlvfgemtdifanagnledlmsnitnrsdindtgffmnleedmtryayyysg
igagvlvaayiqvsfwclaagrqihkirkqffhaimrqeigwfdvhdvgelntrltddvs
kinegigdkigmffqsmatfftgfivgftrgwkltlvilaispvlglsaavwakilssft
dkellayakagavaeevlaairtviafggqkkelerynknleeakrigikkaitanisig
aaflliyasyalafwygttlvlsgeysigqvltvffsvligafsvgqaspsieafanarg
aayeifkiidnkpsidsysksghkpdnikgnlefrnvhfsypsrkevkilkglnlkvqsg
qtvalvgnsgcgksttvqlmqrlydptegmvsvdgqdirtinvrflreiigvvsqepvlf
attiaenirygrenvtmdeiekavkeanaydfimklphkfdtlvgergaqlsggqkqria
iaralvrnpkillldeatsaldteseavvqvaldkarkgrttiviahrlstvrnadviag
fddgvivekgnhdelmkekgiyfklvtmqtagnevelenaadeskseidalemssndsrs
slirkrstrrsvrgsqaqdrklstkealdesippvsfwrimklnltewpyfvvgvfcaii
ngglqpafaiifskiigvftriddpetkrqnsnlfsllflalgiisfitfflqgftfgka
geiltkrlrymvfrsmlrqdvswfddpknttgalttrlandaaqvkgaigsrlavitqni
anlgtgiiisfiygwqltllllaivpiiaiagvvemkmlsgqalkdkkelegagkiatea
ienfrtvvsltqeqkfehmyaqslqvpyrnslrkahifgitfsftqammyfsyagcfrfg
aylvahklmsfedvllvfsavvfgamavgqvssfapdyakakisaahiimiiektplids
ysteglmpntlegnvtfgevvfnyptrpdipvlqglslevkkgqtlalvgssgcgkstvv
qllerfydplagkvlldgkeikrlnvqwlrahlgivsqepilfdcsiaeniaygdnsrvv
sqeeivraakeanihafieslpnkystkvgdkgtqlsggqkqriaiaralvrqphillld
eatsaldtesekvvqealdkaregrtciviahrlstiqnadlivvfqngrvkehgthqql
laqkgiyfsmvsvqagtkrq

    Sequence, based on observed residues (ATOM records):
    >7a6fA (A:)
ptvsvfsmfrysnwldklymvvgtlaaiihgaglplmmlvfgemtdifanagnlfmnlee
dmtryayyysgigagvlvaayiqvsfwclaagrqihkirkqffhaimrqeigwfdvhdvg
elntrltddvskinegigdkigmffqsmatfftgfivgftrgwkltlvilaispvlglsa
avwakilssftdkellayakagavaeevlaairtviafggqkkelerynknleeakrigi
kkaitanisigaaflliyasyalafwygttlvlsgeysigqvltvffsvligafsvgqas
psieafanargaayeifkiidnkpsidsysksghkpdnikgnlefrnvhfsypsrkevki
lkglnlkvqsgqtvalvgnsgcgksttvqlmqrlydptegmvsvdgqdirtinvrflrei
igvvsqepvlfattiaenirygrenvtmdeiekavkeanaydfimklphkfdtlvgerga
qlsggqkqriaiaralvrnpkillldeatsaldteseavvqvaldkarkgrttiviahrl
stvrnadviagfddgvivekgnhdelmkekgiyfklvtmqtpvsfwrimklnltewpyfv
vgvfcaiingglqpafaiifskiigvftriddpetkrqnsnlfsllflalgiisfitffl
qgftfgkageiltkrlrymvfrsmlrqdvswfddpknttgalttrlandaaqvkgaigsr
lavitqnianlgtgiiisfiygwqltllllaivpiiaiagvvemkmlsgqalkdkkeleg
agkiateaienfrtvvsltqeqkfehmyaqslqvpyrnslrkahifgitfsftqammyfs
yagcfrfgaylvahklmsfedvllvfsavvfgamavgqvssfapdyakakisaahiimii
ektplidsysteglmpntlegnvtfgevvfnyptrpdipvlqglslevkkgqtlalvgss
gcgkstvvqllerfydplagkvlldgkeikrlnvqwlrahlgivsqepilfdcsiaenia
ygdnsrvvsqeeivraakeanihafieslpnkystkvgdkgtqlsggqkqriaiaralvr
qphillldeatsaldtesekvvqealdkaregrtciviahrlstiqnadlivvfqngrvk
ehgthqqllaqkgiyfsmvsvqag

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7a6fB (B:)
dvlmtqtpvslsvslgdqasiscrssqsivhstgntylewylqkpgqspklliykisnrf
sgvpdrfsgsgsgtdftlkisrveaedlgvyycfqashaprtfgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >7a6fB (B:)
dvlmtqtpvslsvslgdqasiscrssqsivhstgntylewylqkpgqspklliykisnrf
sgvpdrfsgsgsgtdftlkisrveaedlgvyycfqashaprtfgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceatspivksfnrnec

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >7a6fC (C:)
evilvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissgggntyy
pdsvkgrftisrdnaknnlylqmsslrsedtalyycaryyryeawfaswgqgtlvtvsaa
kttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkiep