PDB entry 7a5v

View 7a5v on RCSB PDB site
Description: cryoem structure of a human gamma-aminobutyric acid receptor, the gaba(a)r-beta3 homopentamer, in complex with histamine and megabody mb25 in lipid nanodisc
Deposited on 2020-08-22, released 2020-11-18
The last revision was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: EM
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: GABRB3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28472 (Start-361)
      • insertion (333)
      • linker (362-368)
    • Uniprot P28472 (369-End)
  • Chain 'O':
    Compound: Megabody Mb25
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7A5V (0-End)
  • Heterogens: R16, D10, NAG, OCT, HSM, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7a5vA (A:)
emdekttgwrgghvveglageleqlrarlehhpqgqrepdydipttenlyfqgtgqsvnd
pgnmsfvketvdkllkgydirlrpdfggppvcvgmnidiasidmvsevnmdytltmyfqq
ywrdkrlaysgiplnltldnrvadqlwvpdtyflndkksfvhgvtvknrmirlhpdgtvl
yglritttaacmmdlrrypldeqnctleiesygyttddiefywrggdkavtgverielpq
fsivehrlvsrnvvfatgayprlslsfrlkrnigyfilqtympsilitilswvsfwinyd
asaarvalgittvltmttinthlretlpkipyvtaidmylmgcfvfvflalleyafvnyi
ffsqparaaaidrwsrivfpftfslfnlvywlyyvn

    Sequence, based on observed residues (ATOM records):
    >7a5vA (A:)
gnmsfvketvdkllkgydirlrpdfggppvcvgmnidiasidmvsevnmdytltmyfqqy
wrdkrlaysgiplnltldnrvadqlwvpdtyflndkksfvhgvtvknrmirlhpdgtvly
glritttaacmmdlrrypldeqnctleiesygyttddiefywrggdkavtgverielpqf
sivehrlvsrnvvfatgayprlslsfrlkrnigyfilqtympsilitilswvsfwinyda
saarvalgittvltmttinthlretlpkipyvtaidmylmgcfvfvflalleyafvnyif
fsqparaaaidrwsrivfpftfslfnlvywlyyv

  • Chain 'O':
    Sequence, based on SEQRES records:
    >7a5vO (O:)
qvqlvesggglvqtktttsvidttndaqnlltqaqtivntlkdycpiliakssssnggtn
nantpswqtagggknscatfgaefsaasdminnaqkivqetqqlsanqpknitqphnlnl
nspssltalaqkmlknaqsqaeilklanqvesdfnklssghlkdyigkcdasaissanmt
mqnqknnwgngcagveetqsllktsaadfnnqtpqinqaqnlantliqelgnntyeqlsr
lltndngtnsktsaqainqavnnlneraktlaggttnspayqatllalrsvlglwnsmgy
avicggytkspgennqkdfhytdengngttincggstnsngthsyngtntlkadknvsls
ieqyekiheayqilskalkqaglaplnskgekleahvttskygslrlscaasghtfnypi
mgwfrqapgkerefvgaiswsggstsyadsvkdrftisrdnakntvylemnnlkpedtav
yycaakgrysgglyyptnydywgqgtqvtvsshhhhhhepea

    Sequence, based on observed residues (ATOM records):
    >7a5vO (O:)
qvqlvesggglvqgslrlscaasghtfnypimgwfrqapgkerefvgaiswsggstsyad
svkdrftisrdnakntvylemnnlkpedtavyycaakgrysgglyyptnydywgqgtqvt
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