PDB entry 7a52

View 7a52 on RCSB PDB site
Description: Structure of DYRK1A in complex with compound 6
Class: transferase
Keywords: serine/threonine-protein kinase, phosphoprotein, kinase, sbdd, fbld, small molecule inhibitor, transferase
Deposited on 2020-08-20, released 2021-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (21-352)
      • initiating methionine (0)
      • expression tag (1-20)
      • expression tag (353-354)
    Domains in SCOPe 2.08: d7a52a1, d7a52a2, d7a52a3
  • Chain 'B':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (21-352)
      • initiating methionine (0)
      • expression tag (1-20)
      • expression tag (353-354)
    Domains in SCOPe 2.08: d7a52b1, d7a52b2, d7a52b3
  • Heterogens: QYB, PO4, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7a52A (A:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffaa

    Sequence, based on observed residues (ATOM records): (download) 
    >7a52A (A:)
vprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqa
qievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvsln
ltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyq
yiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgip
pahildqapkarkffeklpdgtwnlkktkdeykppgtrklhnilgvetggpggrragesg
htvadylkfkdlilrmldydpktriqpyyalqhsffaa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7a52B (B:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffaa

    Sequence, based on observed residues (ATOM records): (download) 
    >7a52B (B:)
prgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqaq
ievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvslnl
trkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyqy
iqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgipp
ahildqapkarkffeklpdgtwnlkkeykppgtrklhnilgvetggpggrragesghtva
dylkfkdlilrmldydpktriqpyyalqhsffa