PDB entry 7a4s

View 7a4s on RCSB PDB site
Description: structure of dyrk1a in complex with compound 2
Deposited on 2020-08-20, released 2021-06-30
The last revision was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (21-358)
      • initiating methionine (0)
      • expression tag (1-20)
  • Heterogens: QYE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7a4sA (A:)
mgsshhhhhhssglvprgshmivkngekwmdryeidsligkgsfgqvvkaydrveqewva
ikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynly
dllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikiv
dfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsgane
vdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhni
lgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktade

    Sequence, based on observed residues (ATOM records):
    >7a4sA (A:)
vkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkkaflnqaqievrlle
lmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnfrgvslnltrkfaqq
mctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscqlgqriyqyiqsrfyr
spevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkivevlgippahildqa
pkarkffeklpdgtwnlkktkdreykppgtrklhnilgvetggpggrragesghtvadyl
kfkdlilrmldydpktriqpyyalqhsffkk