PDB entry 7a3t

View 7a3t on RCSB PDB site
Description: Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8
Class: viral protein
Keywords: VIRAL PROTEIN, FLAVIVIRUS, CLASS 2 FUSION PROTEIN, DENGUE, Antibody
Deposited on 2020-08-18, released 2021-12-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-12-22, with a file datestamp of 2021-12-17.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Core protein
    Species: Dengue virus 3 [TaxId:11069]
    Gene: POLY
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A481XTQ0 (0-392)
      • engineered mutation (106)
      • engineered mutation (310)
      • expression tag (393-427)
  • Chain 'H':
    Compound: EDE1 C8 antibody Fab fragment
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7A3T (0-271)
  • Chain 'L':
    Compound: EDE1 C8 antibody Fab fragment
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7A3T (0-216)
    Domains in SCOPe 2.08: d7a3tl1, d7a3tl2
  • Heterogens: SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7a3tL (L:)
rseivltqspatlslspgeratlscrasqsistflawyqhkpgqaprlliydastratgv
parfsgsrsgtdftltistlepedfavyycqqrynwppytfgqgtkveikrtvaapsvfi
fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
tltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7a3tL (L:)
seivltqspatlslspgeratlscrasqsistflawyqhkpgqaprlliydastratgvp
arfsgsrsgtdftltistlepedfavyycqqrynwppytfgqgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrge