PDB entry 6zyu

View 6zyu on RCSB PDB site
Description: Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549
Class: signaling protein
Keywords: glua2-lbd, glua2-s1s2j, ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, l483y, n754s, signaling protein
Deposited on 2020-08-03, released 2021-08-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-08-11, with a file datestamp of 2021-08-06.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor 2,Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19491 (2-116)
      • expression tag (0-1)
      • engineered mutation (93)
      • linker (117-118)
    • Uniprot P19491 (119-263)
      • engineered mutation (241)
    Domains in SCOPe 2.08: d6zyua1, d6zyua2
  • Chain 'B':
    Compound: Glutamate receptor 2,Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19491 (2-116)
      • expression tag (0-1)
      • engineered mutation (93)
      • linker (117-118)
    • Uniprot P19491 (119-263)
      • engineered mutation (241)
    Domains in SCOPe 2.08: d6zyub1, d6zyub2
  • Chain 'C':
    Compound: Glutamate receptor 2,Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19491 (2-116)
      • expression tag (0-1)
      • engineered mutation (93)
      • linker (117-118)
    • Uniprot P19491 (119-263)
      • engineered mutation (241)
    Domains in SCOPe 2.08: d6zyuc1, d6zyuc2
  • Heterogens: QSW, QSZ, GLU, ZN, CAC, ACT, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6zyuA (A:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgsg

    Sequence, based on observed residues (ATOM records): (download) 
    >6zyuA (A:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6zyuB (B:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgsg

    Sequence, based on observed residues (ATOM records): (download) 
    >6zyuB (B:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6zyuC (C:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgsg

    Sequence, based on observed residues (ATOM records): (download) 
    >6zyuC (C:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecg