PDB entry 6zs3

View 6zs3 on RCSB PDB site
Description: Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol
Class: gene regulation
Keywords: bromodomain, complex, small molecule, structural genomics consortium, sgc, transcription, gene regulation
Deposited on 2020-07-15, released 2020-10-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein polybromo-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PBRM1, BAF180, PB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6zs3a_
  • Chain 'B':
    Compound: Protein polybromo-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PBRM1, BAF180, PB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6zs3b_
  • Heterogens: FX5, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6zs3A (A:)
smsgispkkskymtpmqqklnevyeavknytdkrgrrlsaiflrlpsrselpdyyltikk
pmdmekirshmmankyqdidsmvedfvmmfnnactynepesliykdalvlhkvlletrrd
legd

    Sequence, based on observed residues (ATOM records): (download) 
    >6zs3A (A:)
ymtpmqqklnevyeavknytdkrgrrlsaiflrlpsrselpdyyltikkpmdmekirshm
mankyqdidsmvedfvmmfnnactynepesliykdalvlhkvlletrrdl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6zs3B (B:)
smsgispkkskymtpmqqklnevyeavknytdkrgrrlsaiflrlpsrselpdyyltikk
pmdmekirshmmankyqdidsmvedfvmmfnnactynepesliykdalvlhkvlletrrd
legd

    Sequence, based on observed residues (ATOM records): (download) 
    >6zs3B (B:)
kymtpmqqklnevyeavknytdkrgrrlsaiflrlpsrselpdyyltikkpmdmekirsh
mmankyqdidsmvedfvmmfnnactynepesliykdalvlhkvlletrrd