PDB entry 6zoh

View 6zoh on RCSB PDB site
Description: 3-formylrifamycin sv binding to the access pocket of acrb-g619p_g621p l and t protomers
Deposited on 2020-07-07, released 2021-05-19
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multidrug efflux pump subunit AcrB
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: acrB, acrE, b0462, JW0451
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31224 (0-1048)
      • engineered mutation (618)
      • engineered mutation (620)
      • expression tag (1049-1056)
  • Chain 'B':
    Compound: Multidrug efflux pump subunit AcrB
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: acrB, acrE, b0462, JW0451
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31224 (0-1048)
      • engineered mutation (618)
      • engineered mutation (620)
      • expression tag (1049-1056)
  • Chain 'C':
    Compound: Multidrug efflux pump subunit AcrB
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: acrB, acrE, b0462, JW0451
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31224 (0-1048)
      • engineered mutation (618)
      • engineered mutation (620)
      • expression tag (1049-1056)
  • Chain 'D':
    Compound: darpin
    Species: synthetic construct, synthetic [TaxId:32630]
    Gene: artificial gene
    Database cross-references and differences (RAF-indexed):
    • PDB 6ZOH (0-168)
  • Chain 'E':
    Compound: darpin
    Species: synthetic construct, synthetic [TaxId:32630]
    Gene: artificial gene
    Database cross-references and differences (RAF-indexed):
    • PDB 6ZOH (0-168)
  • Heterogens: 3YI, LMT, EDO, GOL, D12, DDQ, DDR, PTY, D10, LPX, HEX, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6zohA (A:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfaprpqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6zohA (A:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfaprpqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6zohB (B:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfaprpqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6zohB (B:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfaprpqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6zohC (C:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfaprpqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6zohC (C:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfaprpqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrf

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6zohD (D:)
mrgshhhhhhgsdlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghl
eivevllkngadvnaydtlgstplhlaahfghleivevllkngadvnakddngitplhla
anrghleivevllkygadvnaqdkfgktafdisinngnedlaeilqkln

    Sequence, based on observed residues (ATOM records):
    >6zohD (D:)
dlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghleivevllkngad
vnaydtlgstplhlaahfghleivevllkngadvnakddngitplhlaanrghleivevl
lkygadvnaqdkfgktafdisinngnedlaeilq

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6zohE (E:)
mrgshhhhhhgsdlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghl
eivevllkngadvnaydtlgstplhlaahfghleivevllkngadvnakddngitplhla
anrghleivevllkygadvnaqdkfgktafdisinngnedlaeilqkln

    Sequence, based on observed residues (ATOM records):
    >6zohE (E:)
lgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghleivevllkngadv
naydtlgstplhlaahfghleivevllkngadvnakddngitplhlaanrghleivevll
kygadvnaqdkfgktafdisinngnedlaeilq