PDB entry 6zlw

View 6zlw on RCSB PDB site
Description: SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit
Class: viral protein
Keywords: Translational Inhibition, SARS-CoV-2, Immune Evasion, Human Ribosome, VIRAL PROTEIN
Deposited on 2020-07-01, released 2020-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: EM
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

• Chain '2':
  Compound: 18S Ribosomal RNA
  Species: Homo sapiens [TaxId:9606]
  
• Chain 'B':
  Compound: 40S Ribosomal protein SA
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08865
• Chain 'C':
  Compound: 40s ribosomal protein s3a
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61247
• Chain 'D':
  Compound: 40S ribosomal protein S2
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P15880
• Chain 'E':
  Compound: 40S ribosomal protein S4, X isoform
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62701 (Start-262)
• Chain 'F':
  Compound: 40S ribosomal protein S3
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P23396
• Chain 'G':
  Compound: 40s ribosomal protein s6
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62753 (0-End)
• Chain 'H':
  Compound: 40S ribosomal protein S7
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62081
• Chain 'I':
  Compound: 40s ribosomal protein s8
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62241
• Chain 'J':
  Compound: 40S ribosomal protein S9
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46781
• Chain 'K':
  Compound: 40S ribosomal protein S5
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46782 (Start-203)
• Chain 'L':
  Compound: 40S ribosomal protein S11
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62280
• Chain 'M':
  Compound: 40S ribosomal protein S10
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46783 (0-End)
• Chain 'N':
  Compound: 40S ribosomal protein S13
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62277
• Chain 'O':
  Compound: 40s ribosomal protein s12
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P25398 (Start-131)
• Chain 'P':
  Compound: 40s ribosomal protein s14
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62263 (Start-150)
• Chain 'Q':
  Compound: 40S ribosomal protein S15
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62841
• Chain 'R':
  Compound: 40S ribosomal protein S16
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62249 (Start-145)
• Chain 'S':
  Compound: 40S ribosomal protein S17
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08708
• Chain 'T':
  Compound: 40S ribosomal protein S18
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62269
• Chain 'U':
  Compound: 40S ribosomal protein S19
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P39019 (Start-144)
• Chain 'V':
  Compound: 40S ribosomal protein S20
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60866
• Chain 'W':
  Compound: 40S ribosomal protein S15a
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62244 (Start-129)
• Chain 'X':
  Compound: 40S ribosomal protein S23
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62266
• Chain 'Y':
  Compound: 40S ribosomal protein S24
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62847
• Chain 'Z':
  Compound: 40S ribosomal protein S21
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P63220 (0-End)
• Chain 'a':
  Compound: 40S ribosomal protein S25
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62851
• Chain 'b':
  Compound: 40S ribosomal protein S27
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P42677
• Chain 'c':
  Compound: 40S ribosomal protein S26
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62854
• Chain 'd':
  Compound: 40S ribosomal protein S28
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62857
• Chain 'e':
  Compound: 40S ribosomal protein S30
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62861 (Start-58)
• Chain 'f':
  Compound: 40S ribosomal protein S29
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62273 (Start-55)
• Chain 'g':
  Compound: Ubiquitin-40S ribosomal protein S27a
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62979
• Chain 'h':
  Compound: 60S ribosomal protein L41
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62945 (0-End)
• Chain 'i':
  Compound: Non-structural protein 1
  Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
  Gene: rep, 1a-1b
  Database cross-references and differences (RAF-indexed):
  • Uniprot P0DTD1 (Start-179)
• Chain 'j':
  Compound: Receptor of activated protein C kinase 1
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P63244
  Domains in SCOPe 2.08: d6zlwj_
• Heterogens: ZN

PDB Chain Sequences:

• Chain '2':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  No sequence available.
  
  
• Chain 'K':
  No sequence available.
  
  
• Chain 'L':
  No sequence available.
  
  
• Chain 'M':
  No sequence available.
  
  
• Chain 'N':
  No sequence available.
  
  
• Chain 'O':
  No sequence available.
  
  
• Chain 'P':
  No sequence available.
  
  
• Chain 'Q':
  No sequence available.
  
  
• Chain 'R':
  No sequence available.
  
  
• Chain 'S':
  No sequence available.
  
  
• Chain 'T':
  No sequence available.
  
  
• Chain 'U':
  No sequence available.
  
  
• Chain 'V':
  No sequence available.
  
  
• Chain 'W':
  No sequence available.
  
  
• Chain 'X':
  No sequence available.
  
  
• Chain 'Y':
  No sequence available.
  
  
• Chain 'Z':
  No sequence available.
  
  
• Chain 'a':
  No sequence available.
  
  
• Chain 'b':
  No sequence available.
  
  
• Chain 'c':
  No sequence available.
  
  
• Chain 'd':
  No sequence available.
  
  
• Chain 'e':
  No sequence available.
  
  
• Chain 'f':
  No sequence available.
  
  
• Chain 'g':
  No sequence available.
  
  
• Chain 'h':
  No sequence available.
  
  
• Chain 'i':
  No sequence available.
  
  
• Chain 'j':
  Sequence, based on SEQRES records: (download)
  

  >6zlwj (j:)
  mteqmtlrgtlkghngwvtqiattpqfpdmilsasrdktiimwkltrdetnygipqralr
  ghshfvsdvvissdgqfalsgswdgtlrlwdlttgtttrrfvghtkdvlsvafssdnrqi
  vsgsrdktiklwntlgvckytvqdeshsewvscvrfspnssnpiivscgwdklvkvwnla
  ncklktnhightgylntvtvspdgslcasggkdgqamlwdlnegkhlytldggdiinalc
  fspnrywlcaatgpsikiwdlegkiivdelkqevistsskaeppqctslawsadgqtlfa
  gytdnlvrvwqvtigtr
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6zlwj (j:)
  teqmtlrgtlkghngwvtqiattpqfpdmilsasrdktiimwkltrdetnygipqralrg
  hshfvsdvvissdgqfalsgswdgtlrlwdlttgtttrrfvghtkdvlsvafssdnrqiv
  sgsrdktiklwntlgvckytvqdeshsewvscvrfspnssnpiivscgwdklvkvwnlan
  cklktnhightgylntvtvspdgslcasggkdgqamlwdlnegkhlytldggdiinalcf
  spnrywlcaatgpsikiwdlegkiivdelkqevistsskaeppqctslawsadgqtlfag
  ytdnlvrvwqvtig