PDB entry 6zgy

View 6zgy on RCSB PDB site
Description: Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide
Class: transferase
Keywords: GALK1, galactokinase 1, fragment screening, allosteric fragment, binding hotspt, TRANSFERASE
Deposited on 2020-06-20, released 2020-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • engineered mutation (258-259)
    Domains in SCOPe 2.08: d6zgya1, d6zgya2
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • engineered mutation (258-259)
    Domains in SCOPe 2.08: d6zgyb1, d6zgyb2
  • Chain 'D':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • engineered mutation (258-259)
    Domains in SCOPe 2.08: d6zgyd1, d6zgyd2
  • Chain 'E':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • engineered mutation (258-259)
    Domains in SCOPe 2.08: d6zgye1, d6zgye2
  • Heterogens: QL5, GAL, HFK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6zgyA (A:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6zgyA (A:)
aalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmt
vlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaap
lpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmp
cgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrr
qceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyr
afgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaa
phamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6zgyB (B:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6zgyB (B:)
aalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmt
vlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaap
lpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmp
cgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrr
qceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyr
afgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaa
phamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6zgyD (D:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6zgyD (D:)
qvaellaeaafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvgspdg
lvsllttqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgfsavvvssvplggg
lsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfaimdqfislmgqkghallidc
rsletslvplsdpklavlitnsnvrhslasseypvrrrqceevaralgaaslrevqleel
eaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmveshrslrddyevscp
eldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiqehyggtatfylsqa
adgakvlcl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6zgyE (E:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6zgyE (E:)
aalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmt
vlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaap
lpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmp
cgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrr
qceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyr
afgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaa
phamrhiqehyggtatfylsqaadgakvlcl