PDB entry 6zfh

View 6zfh on RCSB PDB site
Description: Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one
Class: transferase
Keywords: GHMP Kinase, Galactose metabolism, Inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2020-06-17, released 2021-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 2.44 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfha1, d6zfha2
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhb1, d6zfhb2
  • Chain 'C':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhc1, d6zfhc2, d6zfhc3
  • Chain 'D':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhd1, d6zfhd2
  • Chain 'E':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhe1, d6zfhe2
  • Chain 'F':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhf1, d6zfhf2
  • Chain 'G':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhg1, d6zfhg2
  • Chain 'H':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • initiating methionine (0)
      • expression tag (1-7)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6zfhh1, d6zfhh2
  • Heterogens: GAL, QV2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6zfhA (A:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhA (A:)
    alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
    lvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaapl
    pgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpc
    gimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrsseypvrrrqceev
    aralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrl
    mveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamr
    hiqehyggtatfylsqaadgakvlcl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6zfhB (B:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhB (B:)
    lrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvl
    vgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplp
    gfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcg
    imdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrasseypvrrrqceev
    aralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrl
    mveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamr
    hiqehyggtatfylsqaadgakvlcl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6zfhC (C:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhC (C:)
    haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
    tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
    plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
    pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhseypvrrrqce
    evaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafg
    rlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaapha
    mrhiqehyggtatfylsqaadgakvlcl
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6zfhD (D:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhD (D:)
    lrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvl
    vgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplp
    gfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcg
    imdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhseypvrrrqceeva
    ralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlm
    veshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrh
    iqehyggtatfylsqaadgakvlcl
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >6zfhE (E:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhE (E:)
    alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
    lvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaapl
    pgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpc
    gimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvasseypvrrrqceev
    aralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrl
    mveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamr
    hiqehyggtatfylsqaadgakvlcl
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >6zfhF (F:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhF (F:)
    alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
    lvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypalpg
    fsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgi
    mdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrsseypvrrrqceevar
    algaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmv
    eshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhi
    qehyggtatfylsqaadgakvlcl
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >6zfhG (G:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhG (G:)
    qpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvg
    sprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgf
    savvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgim
    dqfislmgqkghallidcrsletslvplsdpklavlitnsnvrsseypvrrrqceevara
    lgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmve
    shrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiq
    ehyggtatfylsqaadgakvlcl
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >6zfhH (H:)
    mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
    pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
    iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
    ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
    seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
    alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
    tlleasaaphamrhiqehyggtatfylsqaadgakvlcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6zfhH (H:)
    pqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvgs
    prkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgfs
    avvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgimd
    qfislmgqkghallidcrsletslvplsdpklavlitnsnvpvrrrqceevaralgaasl
    revqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmveshrslr
    ddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiqehyggt
    atfylsqaadgakvlc