PDB entry 6zc7
View 6zc7 on RCSB PDB site
Description: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Class: peptide binding protein
Keywords: PDZ, DVL, Inhibitors, Wnt, signalling, PEPTIDE BINDING PROTEIN
Deposited on
2020-06-09, released
2021-06-23
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-06-23, with a file datestamp of
2021-06-18.
Experiment type: XRAY
Resolution: 1.48 Å
R-factor: N/A
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b
Species: Homo sapiens [TaxId:9606]
Gene: DKFZp586M1622, DVL3, hCG_40299
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6zc7a1, d6zc7a2 - Chain 'B':
Compound: Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b
Species: Homo sapiens [TaxId:9606]
Gene: DKFZp586M1622, DVL3, hCG_40299
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6zc7b1, d6zc7b2 - Heterogens: V31, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6zc7A (A:)
amslniitvtlnmekynflgisivgqsnergdggiyigsimkggavaadgriepgdmllq
vneinfenmsnddavrvlreivhkpgpitltvaks
Sequence, based on observed residues (ATOM records): (download)
>6zc7A (A:)
slniitvtlnmekynflgisivgqsergdggiyigsimkggavaadgriepgdmllqvne
infenmsnddavrvlreivhkpgpitltvaks
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6zc7B (B:)
amslniitvtlnmekynflgisivgqsnergdggiyigsimkggavaadgriepgdmllq
vneinfenmsnddavrvlreivhkpgpitltvaks
Sequence, based on observed residues (ATOM records): (download)
>6zc7B (B:)
mslniitvtlnmekynflgisivgqsnergdggiyigsimkggavaadgriepgdmllqv
neinfenmsnddavrvlreivhkpgpitltvaks