PDB entry 6z7w

View 6z7w on RCSB PDB site
Description: Human insulin in complex with the analytical antibody HUI-018 Fab
Class: hormone
Keywords: complex, insulin, analytical antibody, Fab, HORMONE
Deposited on 2020-06-02, released 2020-12-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MAb 6H10 light chain
    Species: Mus musculus [TaxId:10090]
    Gene: LC
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-213)
    Domains in SCOPe 2.08: d6z7wa1, d6z7wa2
  • Chain 'B':
    Compound: HUI-018 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-223)
    Domains in SCOPe 2.08: d6z7wb1, d6z7wb2
  • Chain 'C':
    Compound: MAb 6H10 light chain
    Species: Mus musculus [TaxId:10090]
    Gene: LC
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-End)
    Domains in SCOPe 2.08: d6z7wc1, d6z7wc2
  • Chain 'D':
    Compound: HUI-018 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-End)
    Domains in SCOPe 2.08: d6z7wd1, d6z7wd2
  • Chain 'E':
    Compound: MAb 6H10 light chain
    Species: Mus musculus [TaxId:10090]
    Gene: LC
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-213)
    Domains in SCOPe 2.08: d6z7we1, d6z7we2
  • Chain 'F':
    Compound: HUI-018 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-End)
    Domains in SCOPe 2.08: d6z7wf1, d6z7wf2
  • Chain 'G':
    Compound: MAb 6H10 light chain
    Species: Mus musculus [TaxId:10090]
    Gene: LC
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-213)
    Domains in SCOPe 2.08: d6z7wg1, d6z7wg2
  • Chain 'H':
    Compound: HUI-018 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z7W (0-End)
    Domains in SCOPe 2.08: d6z7wh1, d6z7wh2
  • Chain 'I':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6z7wA (A:)
divmtqsqkfmstsvgdrvsitckasqnvrtavawyqqrpgqspkaliylasnrhtgvpd
rftgsgsgtdftltitnvqsedladyfclqhwnypltfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6z7wB (B:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqs
dlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

    Sequence, based on observed residues (ATOM records): (download) 
    >6z7wB (B:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapgsnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlyt
lsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6z7wC (C:)
divmtqsqkfmstsvgdrvsitckasqnvrtavawyqqrpgqspkaliylasnrhtgvpd
rftgsgsgtdftltitnvqsedladyfclqhwnypltfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6z7wC (C:)
divmtqsqkfmstsvgdrvsitckasqnvrtavawyqqrpgqspkaliylasnrhtgvpd
rftgsgsgtdftltitnvqsedladyfclqhwnypltfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrne

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6z7wD (D:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqs
dlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

    Sequence, based on observed residues (ATOM records): (download) 
    >6z7wD (D:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlss
svtvpsstwpsetvtcnvahpasstkvdkkivp

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6z7wE (E:)
divmtqsqkfmstsvgdrvsitckasqnvrtavawyqqrpgqspkaliylasnrhtgvpd
rftgsgsgtdftltitnvqsedladyfclqhwnypltfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6z7wF (F:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqs
dlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

    Sequence, based on observed residues (ATOM records): (download) 
    >6z7wF (F:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlss
svtvpsstwpsetvtcnvahpasstkvdkkivprdc

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6z7wG (G:)
divmtqsqkfmstsvgdrvsitckasqnvrtavawyqqrpgqspkaliylasnrhtgvpd
rftgsgsgtdftltitnvqsedladyfclqhwnypltfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6z7wH (H:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqs
dlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

    Sequence, based on observed residues (ATOM records): (download) 
    >6z7wH (H:)
qvqlqqsgaelvrpgtsvkvsckasgyaftnhliewvnqrpgqglewigvinpgsggtky
nekfkgkatltadkssstaymqlsrltsddsavyfcarssefittvaadywgqgttltvs
sakttppsvyplapgsnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlyt
lsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.