PDB entry 6z3a

View 6z3a on RCSB PDB site
Description: mec1-ddc2 (wild-type) in complex with amp-pnp
Deposited on 2020-05-19, released 2020-11-11
The last revision was dated 2021-02-10, with a file datestamp of 2021-02-05.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: DNA damage checkpoint protein LCD1
    Species: SACCHAROMYCES CEREVISIAE S288C [TaxId:559292]
    Gene: LCD1, DDC2, PIE1, YDR499W
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA damage checkpoint protein LCD1
    Species: SACCHAROMYCES CEREVISIAE S288C [TaxId:559292]
    Gene: LCD1, DDC2, PIE1, YDR499W
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Serine/threonine-protein kinase MEC1
    Species: SACCHAROMYCES CEREVISIAE S288C [TaxId:559292]
    Gene: MEC1, ESR1, SAD3, YBR136W, YBR1012
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Serine/threonine-protein kinase MEC1
    Species: SACCHAROMYCES CEREVISIAE S288C [TaxId:559292]
    Gene: MEC1, ESR1, SAD3, YBR136W, YBR1012
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ANP, ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6z3aC (C:)
mrretvgefssdddddillelgtrpprftqippssaalqtqipttlevttttlnnkqskn
dnqlvnqlnkaqgeasmlrdkinflnierekekniqavkvnelqvkhlqelaklkqelqk
ledekkflqmeargkskrevitnvkppsttlstntntitpdsssvaieakpqspqskkrk
isdnllkknmvplnpnriipdetslflesillhqiigadlstieilnrlkldyitefkfk
nfviakgapigksivslllrckktltldrfidtllediavlikeisvhpnesklavpflv
almyqivqfrpsathnlalkdcflficdliriyhhvlkvpihesnmnlhvepqifqyeli
dyliisysfdllegilrvlqshpkqtymeffdenilksfefvyklaltisykpmvnvifs
avevvniitsiilnmdnssdlkslisgswwrdcitrlyallekeiksgdvynenvdtttl
hmskyhdffglirnigdnelggliskliytdrlqsvprviskedigmdsdkftapiigyk
mekwllklkdevlnifenllmiygddativngemlihsskflsreqalmieryvgqdspn
ldlrchliehtltiiyrlwkdhfkqlreeqikqvesqlimslwrflvcqtetvtanerem
rdhrhlvdslhdltikdqasyyedafedlpeyieeelkmqlnkrtgrimqvkydekfqem
artilesksfdlttleeadslyismgl

    Sequence, based on observed residues (ATOM records):
    >6z3aC (C:)
nmvplnpnriipdetslflesillhqiigadlstieilnrlkldyitefkfknfviakga
pigksivslllrckktltldrfidtllediavlikeisvhpnesklavpflvalmyqivq
frpsathnlalkdcflficdliriyhhvlkvpihesnmnlhvepqifqyelidyliisys
fdllegilrvlqshpkqtymeffdenilksfefvyklaltisykpmvnvifsavevvnii
tsiilnmdnssdlkslisgswwrdcitrlyallekeiksgdvynenvdtttlhmskyhdf
fglirnigdnelggliskliytdrlqsvprviskedigftapiigykmekwllklkdevl
nifenllmiygddativngemlihsskflsreqalmieryvgqdspnldlrchliehtlt
iiyrlwkdhfkqlreeqikqvesqlimslwrflvcqtetvtaneremrdhrhlvdslhdl
tikdqasyyedafedlpeyieeelkmqlnkrtgrimqvkydekfqemartilesksfdlt
tleeadslyismgl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6z3aD (D:)
mrretvgefssdddddillelgtrpprftqippssaalqtqipttlevttttlnnkqskn
dnqlvnqlnkaqgeasmlrdkinflnierekekniqavkvnelqvkhlqelaklkqelqk
ledekkflqmeargkskrevitnvkppsttlstntntitpdsssvaieakpqspqskkrk
isdnllkknmvplnpnriipdetslflesillhqiigadlstieilnrlkldyitefkfk
nfviakgapigksivslllrckktltldrfidtllediavlikeisvhpnesklavpflv
almyqivqfrpsathnlalkdcflficdliriyhhvlkvpihesnmnlhvepqifqyeli
dyliisysfdllegilrvlqshpkqtymeffdenilksfefvyklaltisykpmvnvifs
avevvniitsiilnmdnssdlkslisgswwrdcitrlyallekeiksgdvynenvdtttl
hmskyhdffglirnigdnelggliskliytdrlqsvprviskedigmdsdkftapiigyk
mekwllklkdevlnifenllmiygddativngemlihsskflsreqalmieryvgqdspn
ldlrchliehtltiiyrlwkdhfkqlreeqikqvesqlimslwrflvcqtetvtanerem
rdhrhlvdslhdltikdqasyyedafedlpeyieeelkmqlnkrtgrimqvkydekfqem
artilesksfdlttleeadslyismgl

    Sequence, based on observed residues (ATOM records):
    >6z3aD (D:)
nmvplnpnriipdetslflesillhqiigadlstieilnrlkldyitefkfknfviakga
pigksivslllrckktltldrfidtllediavlikeisvhpnesklavpflvalmyqivq
frpsathnlalkdcflficdliriyhhvlkvpihesnmnlhvepqifqyelidyliisys
fdllegilrvlqshpkqtymeffdenilksfefvyklaltisykpmvnvifsavevvnii
tsiilnmdnssdlkslisgswwrdcitrlyallekeiksgdvynenvdtttlhmskyhdf
fglirnigdnelggliskliytdrlqsvprviskedigftapiigykmekwllklkdevl
nifenllmiygddativngemlihsskflsreqalmieryvgqdspnldlrchliehtlt
iiyrlwkdhfkqlreeqikqvesqlimslwrflvcqtetvtaneremrdhrhlvdslhdl
tikdqasyyedafedlpeyieeelkmqlnkrtgrimqvkydekfqemartilesksfdlt
tleeadslyismgl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6z3aE (E:)
meshvkyldelilaikdlnsgvdskvqikkvptdpsssqeyakslkilntlirnlkdqrr
nnimkndtifsktvsalallleynpfllvmkdsngnfeiqrliddflnisvlnydnyhri
wfmrrklgswckacvefygkpakfqltahfentmnlyeqaltevllgktellkfydtlkg
lyillywftseystfgnsiafldsslgftkfdfnfqrlirivlyvfdscelaaleyaeiq
lkyislvvdyvcnrtistaldapalvcceqlkfvlttmhhfldnkyglldndptmakgil
rlyslcisndfskcfvdhfpidqwadfsqsehfpftqltnkalsivyfdlkrrslpveal
kydnkfniwvyqsepdsslknvtspfddrykqleklrllvlkkfnktergtllkyrvnql
spgffqragndfklilneasvsiqtcfktnnitrltswtvilgrlaclesekfsgtlpns
tkdmdnwyvchlcdiektgnpfvrinpnrpeaagkseifrilhsnflshpnidefsesll
sgilfslhrifshfqppkltdgngqinksfklvqkcfmnsnrylrllstriiplfnisds
hnsedehtatlikflqsqklpvvkenlviawtqltlttsndvfdtlllklidifnsddys
lrimmtlqiknmakilkktpyqllspilpvllrqlgknlverkvgfqnliellgysskti
ldifqryiipyaiiqyksdvlseiakimcdgdtslinqmkvnllkknsrqifavalvkhg
lfsldiletlflnraptfdkgyitaylpdyktlaeitklyknsvtkdasdsenanmilcs
lrflitnfekdkrhgskykninnwtddqeqafqkklqdnilgifqvfssdihdvegrtty
yeklrvingisfliiyapkksiisalaqisiclqtglglkevryeafrcwhllvrhlnde
elstvidsliafilqkwsefngklrnivysildtlikeksdlilklkpyttlalvgkpel
gilardgqfarmvnkirsttdlipifannlkssnkyvinqnlddievylrrkqtersidf
tpkkvgqtsditlvlgalldtshkfrnldkdlcekcakcismigvldvtkhefkrttyse
nevydlndsvqtikfliwvindilvpafwqsenpskqlfvalviqeslkycglsseswdm
nhkelypneaklwekfnsvskttiypllsslylaqswkeyvplkypsnnfkegykiwvkr
ftldllktgttenhplhvfsslireddgslsnfllpyisldiiikaekgtpyadilngii
iefdsiftcnlegmnnlqvdslrmcyesifrvfeyckkwatefkqnysklhgtfiikdtk
ttnmllrideflrttpsdllaqrsletdsfersalyleqcyrqnphdknqngqllknlqi
tyeeigdidsldgvlrtfatgnlvskieelqysenwklaqdcfnvlgkfsddpktttrml
ksmydhqlysqiisnssfhssdgkislspdvkewysigleaanlegnvqtlknwveqies
lrniddrevllqyniakaliaisnedplrtqkyihnsfrligtnfitsskettllkkqnl
lmklhslydlsflssakdkfeyksnttildyrmerigadfvpnhyilsmrksfdqlkmne
qadadlgktfftlaqlarnnarldiaseslmhclerrlpqaelefaeilwkqgendralk
ivqeihekyqenssvnardraavllkftewldlsnnsaseqiikqyqdifqidskwdkpy
ysiglyysrllerkkaegyitngrfeyraisyfllafekntakvrenlpkvitfwldiaa
asiseapgnrkemlskatedicshveealqhcptyiwyfvltqllsrllhshqssaqiim
hillslaveypshilwyitalvnsnsskrvlrgkhilekyrqhsqnphdlvssaldltka
ltrvclqdvksitsrsgkslekdfkfdmnvapsamvvpvrknldiisplesnsmrgyqpf
rpvvsiirfgssykvfsslkkpkqlniigsdgniygimckkedvrqdnqymqfattmdfl
lskdiasrkrslginiysvlslredcgilemvpnvvtlrsilstkyeslkikyslkslhd
rwqhtavdgklefymeqvdkfppilyqwflenfpdpinwfnarntyarsyavmamvghil
glgdrhcenilldiqtgkvlhvdfdclfekgkrlpvpeivpfrltpnlldalgiigtegt
fkkssevtlalmrknevalmnvietimydrnmdhsiqkalkvlrnkirgidpqdglvlsv
agqtetliqeatsednlskmyigwlpfw

    Sequence, based on observed residues (ATOM records):
    >6z3aE (E:)
eshvkyldelilaikdlnsgvdskvqikkvpslkilntlirnlkdqrrnnimkndtifsk
tvsalallleynpfllvmkdsngnfeiqrliddflnisvlnydnyhriwfmrrklgswck
acvefygkpakfqltahfentmnlyeqaltevllgktellkfydtlkglyillywftsey
stfgnsiafldsslgftkfdfnfqrlirivlyvfdscelaaleyaeiqlkyislvvdyvc
nrtistaldapalvcceqlkfvlttmhhfldnkyglldndptmakgilrlyslcisndfs
kcfvdhfpidqwadfsqsehfpftqltnkalsivyfdlkrrslpvealkydnkfniwvyq
sepdsslknvtspfddrykqleklrllvlkkfnktergtllkyrvnqlspgffqragndf
klilneasvsiqtcfktnnitrltswtvilgrlaclesekfsstkdmdnwyvchlcdiek
tgnpfvrinpnrpeaagkseifrilhsnflshpnidefsesllsgilfslhrifshfqpp
kltdgngqinksfklvqkcfmnsnrylrllstriiplfnisdshnsedehtatlikflqs
qklpvvkenlviawtqltlttsndvfdtlllklidifnsddyslrimmtlqiknmakilk
ktpyqllspilpvllrqlgknlverkvgfqnliellgyssktildifqryiipyaiiqyk
sdvlseiakimcdgdtslinqmkvnllkknsrqifavalvkhglfsldiletlflnrapt
fdkgyitaylpdyktlaeitklyknsvtkdasdsenanmilcslrflitnfekdskykni
nnwtddqeqafqkklqdnilgifqvfssdihdvegrttyyeklrvingisfliiyapkks
iisalaqisiclqtglglkevryeafrcwhllvrhlndeelstvidsliafilqkwsefn
gklrnivysildtlikeksdlilklkpyttlalvgkpelgilardgqfarmvnkirsttd
lipifannlkssnkyvinqnlddievylrrkqtersidftpditlvlgalldtshkfrnl
dkdlcekcakcismigvldvtkhefkrenevydlndsvqtikfliwvindilvpafwqse
npskqlfvalviqeslkycglsseswdmnhkelypneaklwekfnsvskttiypllssly
laqswkeyvplkypsnnfkegykiwvkrftldllktgttenhplhvfssligslsnfllp
yisldiiikaekgtpyadilngiiiefdsiftcnlegmnnlqvdslrmcyesifrvfeyc
kkwatefkqnysklhgtfiikdtkttnmllrideflrttpsdllaqrsletdsfersaly
leqcyrqnphdknqngqllknlqityeeigdidsldgvlrtfatgnlvskieelqysenw
klaqdcfnvlgkfsddpktttrmlksmydhqlysqiisnssfhssdgkislspdvkewys
igleaanlegnvqtlknwveqieslrniddrevllqyniakaliaisnedplrtqkyihn
sfrligtnfitsskettllkkqnllmklhslydlsflssakdkfeyksnttildyrmeri
gadfvpnhyilsmrksfdqlkmneqadadlgktfftlaqlarnnarldiaseslmhcler
rlpqaelefaeilwkqgendralkivqeihekyqenssvnardraavllkftewldlsnn
saseqiikqyqdifqidskwdkpyysiglyysrllerkkaegyitngrfeyraisyflla
fekntakvrenlpkvitfwldiaaasisearkemlskatedicshveealqhcptyiwyf
vltqllsrllhshqssaqiimhillslaveypshilwyitalvnsnsskrvlrgkhilek
yrqhsqnphdlvssaldltkaltrvclqdvkfkfdmnvapsamvvpvrknldiisplegy
qpfrpvvsiirfgssykvfsslkkpkqlniigsdgniygimckkedvrqdnqymqfattm
dfllskdiasrkrslginiysvlslredcgilemvpnvvtlrsilstkyeslkikyslks
lhdrwqhtavdgklefymeqvdkfppilyqwflenfpdpinwfnarntyarsyavmamvg
hilglgdrhcenilldiqtgkvlhvdfdclfekgkrlpvpeivpfrltpnlldalgiigt
egtfkkssevtlalmrknevalmnvietimydrnmdhsiqkalkvlrnkirgidpqdglv
lsvagqtetliqeatsednlskmyigwlpfw

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6z3aF (F:)
meshvkyldelilaikdlnsgvdskvqikkvptdpsssqeyakslkilntlirnlkdqrr
nnimkndtifsktvsalallleynpfllvmkdsngnfeiqrliddflnisvlnydnyhri
wfmrrklgswckacvefygkpakfqltahfentmnlyeqaltevllgktellkfydtlkg
lyillywftseystfgnsiafldsslgftkfdfnfqrlirivlyvfdscelaaleyaeiq
lkyislvvdyvcnrtistaldapalvcceqlkfvlttmhhfldnkyglldndptmakgil
rlyslcisndfskcfvdhfpidqwadfsqsehfpftqltnkalsivyfdlkrrslpveal
kydnkfniwvyqsepdsslknvtspfddrykqleklrllvlkkfnktergtllkyrvnql
spgffqragndfklilneasvsiqtcfktnnitrltswtvilgrlaclesekfsgtlpns
tkdmdnwyvchlcdiektgnpfvrinpnrpeaagkseifrilhsnflshpnidefsesll
sgilfslhrifshfqppkltdgngqinksfklvqkcfmnsnrylrllstriiplfnisds
hnsedehtatlikflqsqklpvvkenlviawtqltlttsndvfdtlllklidifnsddys
lrimmtlqiknmakilkktpyqllspilpvllrqlgknlverkvgfqnliellgysskti
ldifqryiipyaiiqyksdvlseiakimcdgdtslinqmkvnllkknsrqifavalvkhg
lfsldiletlflnraptfdkgyitaylpdyktlaeitklyknsvtkdasdsenanmilcs
lrflitnfekdkrhgskykninnwtddqeqafqkklqdnilgifqvfssdihdvegrtty
yeklrvingisfliiyapkksiisalaqisiclqtglglkevryeafrcwhllvrhlnde
elstvidsliafilqkwsefngklrnivysildtlikeksdlilklkpyttlalvgkpel
gilardgqfarmvnkirsttdlipifannlkssnkyvinqnlddievylrrkqtersidf
tpkkvgqtsditlvlgalldtshkfrnldkdlcekcakcismigvldvtkhefkrttyse
nevydlndsvqtikfliwvindilvpafwqsenpskqlfvalviqeslkycglsseswdm
nhkelypneaklwekfnsvskttiypllsslylaqswkeyvplkypsnnfkegykiwvkr
ftldllktgttenhplhvfsslireddgslsnfllpyisldiiikaekgtpyadilngii
iefdsiftcnlegmnnlqvdslrmcyesifrvfeyckkwatefkqnysklhgtfiikdtk
ttnmllrideflrttpsdllaqrsletdsfersalyleqcyrqnphdknqngqllknlqi
tyeeigdidsldgvlrtfatgnlvskieelqysenwklaqdcfnvlgkfsddpktttrml
ksmydhqlysqiisnssfhssdgkislspdvkewysigleaanlegnvqtlknwveqies
lrniddrevllqyniakaliaisnedplrtqkyihnsfrligtnfitsskettllkkqnl
lmklhslydlsflssakdkfeyksnttildyrmerigadfvpnhyilsmrksfdqlkmne
qadadlgktfftlaqlarnnarldiaseslmhclerrlpqaelefaeilwkqgendralk
ivqeihekyqenssvnardraavllkftewldlsnnsaseqiikqyqdifqidskwdkpy
ysiglyysrllerkkaegyitngrfeyraisyfllafekntakvrenlpkvitfwldiaa
asiseapgnrkemlskatedicshveealqhcptyiwyfvltqllsrllhshqssaqiim
hillslaveypshilwyitalvnsnsskrvlrgkhilekyrqhsqnphdlvssaldltka
ltrvclqdvksitsrsgkslekdfkfdmnvapsamvvpvrknldiisplesnsmrgyqpf
rpvvsiirfgssykvfsslkkpkqlniigsdgniygimckkedvrqdnqymqfattmdfl
lskdiasrkrslginiysvlslredcgilemvpnvvtlrsilstkyeslkikyslkslhd
rwqhtavdgklefymeqvdkfppilyqwflenfpdpinwfnarntyarsyavmamvghil
glgdrhcenilldiqtgkvlhvdfdclfekgkrlpvpeivpfrltpnlldalgiigtegt
fkkssevtlalmrknevalmnvietimydrnmdhsiqkalkvlrnkirgidpqdglvlsv
agqtetliqeatsednlskmyigwlpfw

    Sequence, based on observed residues (ATOM records):
    >6z3aF (F:)
eshvkyldelilaikdlnsgvdskvqikkvpslkilntlirnlkdqrrnnimkndtifsk
tvsalallleynpfllvmkdsngnfeiqrliddflnisvlnydnyhriwfmrrklgswck
acvefygkpakfqltahfentmnlyeqaltevllgktellkfydtlkglyillywftsey
stfgnsiafldsslgftkfdfnfqrlirivlyvfdscelaaleyaeiqlkyislvvdyvc
nrtistaldapalvcceqlkfvlttmhhfldnkyglldndptmakgilrlyslcisndfs
kcfvdhfpidqwadfsqsehfpftqltnkalsivyfdlkrrslpvealkydnkfniwvyq
sepdsslknvtspfddrykqleklrllvlkkfnktergtllkyrvnqlspgffqragndf
klilneasvsiqtcfktnnitrltswtvilgrlaclesekfsstkdmdnwyvchlcdiek
tgnpfvrinpnrpeaagkseifrilhsnflshpnidefsesllsgilfslhrifshfqpp
kltdgngqinksfklvqkcfmnsnrylrllstriiplfnisdshnsedehtatlikflqs
qklpvvkenlviawtqltlttsndvfdtlllklidifnsddyslrimmtlqiknmakilk
ktpyqllspilpvllrqlgknlverkvgfqnliellgyssktildifqryiipyaiiqyk
sdvlseiakimcdgdtslinqmkvnllkknsrqifavalvkhglfsldiletlflnrapt
fdkgyitaylpdyktlaeitklyknsvtkdasdsenanmilcslrflitnfekdskykni
nnwtddqeqafqkklqdnilgifqvfssdihdvegrttyyeklrvingisfliiyapkks
iisalaqisiclqtglglkevryeafrcwhllvrhlndeelstvidsliafilqkwsefn
gklrnivysildtlikeksdlilklkpyttlalvgkpelgilardgqfarmvnkirsttd
lipifannlkssnkyvinqnlddievylrrkqtersidftpditlvlgalldtshkfrnl
dkdlcekcakcismigvldvtkhefkrenevydlndsvqtikfliwvindilvpafwqse
npskqlfvalviqeslkycglsseswdmnhkelypneaklwekfnsvskttiypllssly
laqswkeyvplkypsnnfkegykiwvkrftldllktgttenhplhvfssligslsnfllp
yisldiiikaekgtpyadilngiiiefdsiftcnlegmnnlqvdslrmcyesifrvfeyc
kkwatefkqnysklhgtfiikdtkttnmllrideflrttpsdllaqrsletdsfersaly
leqcyrqnphdknqngqllknlqityeeigdidsldgvlrtfatgnlvskieelqysenw
klaqdcfnvlgkfsddpktttrmlksmydhqlysqiisnssfhssdgkislspdvkewys
igleaanlegnvqtlknwveqieslrniddrevllqyniakaliaisnedplrtqkyihn
sfrligtnfitsskettllkkqnllmklhslydlsflssakdkfeyksnttildyrmeri
gadfvpnhyilsmrksfdqlkmneqadadlgktfftlaqlarnnarldiaseslmhcler
rlpqaelefaeilwkqgendralkivqeihekyqenssvnardraavllkftewldlsnn
saseqiikqyqdifqidskwdkpyysiglyysrllerkkaegyitngrfeyraisyflla
fekntakvrenlpkvitfwldiaaasisearkemlskatedicshveealqhcptyiwyf
vltqllsrllhshqssaqiimhillslaveypshilwyitalvnsnsskrvlrgkhilek
yrqhsqnphdlvssaldltkaltrvclqdvkfkfdmnvapsamvvpvrknldiisplegy
qpfrpvvsiirfgssykvfsslkkpkqlniigsdgniygimckkedvrqdnqymqfattm
dfllskdiasrkrslginiysvlslredcgilemvpnvvtlrsilstkyeslkikyslks
lhdrwqhtavdgklefymeqvdkfppilyqwflenfpdpinwfnarntyarsyavmamvg
hilglgdrhcenilldiqtgkvlhvdfdclfekgkrlpvpeivpfrltpnlldalgiigt
egtfkkssevtlalmrknevalmnvietimydrnmdhsiqkalkvlrnkirgidpqdglv
lsvagqtetliqeatsednlskmyigwlpfw