PDB entry 6z2f

View 6z2f on RCSB PDB site
Description: Crystal structure of human AGX1 mutant complexed with UDPGLCNAC
Class: biosynthetic protein
Keywords: Hexosamine biosynthetic pathway AGX1 Disease mutant, BIOSYNTHETIC PROTEIN
Deposited on 2020-05-15, released 2021-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: UDP-N-acetylhexosamine pyrophosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: UAP1, SPAG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16222
      • engineered mutation (232)
    Domains in SCOPe 2.08: d6z2fa_
  • Chain 'B':
    Compound: UDP-N-acetylhexosamine pyrophosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: UAP1, SPAG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16222
      • engineered mutation (232)
    Domains in SCOPe 2.08: d6z2fb_
  • Heterogens: UD1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6z2fA (A:)
gpelmnindlkltlskagqehllrfwneleeaqqvelyaelqamnfeelnfffqkaiegf
nqssyqknvdarmepvprevlgsatrdqdqlqaweseglfqisqnkvavlllaggqgtrl
gvaypkgmydvglpsrktlfqiqaerilklqqvaekyygnkciipwyimtsgrtmestke
fftkhkyfglkkenviffqqgmlpamsfdgkiileeknkvsmapdgngglyrtlaaqniv
edmeqrgiwsihvycvdnilvkvadprfigfciqkgadcgakvvektnptepvgvvcrvd
gvyqvveyseislataqkrssdgrllfnagnianhfftvpflrdvvnvyepqlqhhvaqk
kipyvdtqgqlikpdkpngikmekfvfdifqfakkfvvyevlredefsplknadsqngkd
npttarhalmslhhcwvlnagghfidengsrlpaiprlkdandvpiqceisplisyageg
lesyvadkefhapliidengvhelvkngi

    Sequence, based on observed residues (ATOM records): (download) 
    >6z2fA (A:)
nindlkltlskagqehllrfwneleeaqqvelyaelqamnfeelnfffqkaiemepvprd
qlqaweseglfqisqnkvavlllarlgvaypkgmydvglpsrktlfqiqaerilklqqva
ekyygnkciipwyimtsgtmestkefftkhkyfglkkenviffqqgmlpamsfdgkiile
eknkvsmapdgngglyrtlaaqnivedmeqrgiwsihvycvdnilvkvadprfigfciqk
gadcgakvvektnptepvgvvcrvgvyqvveyseislataqkrssdgrllfnagnianhf
ftvpflrdvvnvyepqlqhhvaqkkipyvdtqgqlikpdkpngikmekfvfdifqfakkf
vvyevlredefsplknadsqngkdnpttarhalmslhhcwvlnagghfidengsrlpaip
rlkdandvpiqceisplisyageglesyvadkefhapliidengvhelv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6z2fB (B:)
gpelmnindlkltlskagqehllrfwneleeaqqvelyaelqamnfeelnfffqkaiegf
nqssyqknvdarmepvprevlgsatrdqdqlqaweseglfqisqnkvavlllaggqgtrl
gvaypkgmydvglpsrktlfqiqaerilklqqvaekyygnkciipwyimtsgrtmestke
fftkhkyfglkkenviffqqgmlpamsfdgkiileeknkvsmapdgngglyrtlaaqniv
edmeqrgiwsihvycvdnilvkvadprfigfciqkgadcgakvvektnptepvgvvcrvd
gvyqvveyseislataqkrssdgrllfnagnianhfftvpflrdvvnvyepqlqhhvaqk
kipyvdtqgqlikpdkpngikmekfvfdifqfakkfvvyevlredefsplknadsqngkd
npttarhalmslhhcwvlnagghfidengsrlpaiprlkdandvpiqceisplisyageg
lesyvadkefhapliidengvhelvkngi

    Sequence, based on observed residues (ATOM records): (download) 
    >6z2fB (B:)
indlkltlskagqehllrfwneleeaqqvelyaelqamnfeelnfffqkaiegfvdarme
pvplqaweseglfqisqnkvavlllaggqgtrlgvaypkgmydvglpsrktlfqiqaeri
lklqqvaekyygnkciipwyimtsgrtmestkefftkhkyfglkkenviffqqgmlpams
fdgkiileeknkvsmapdgngglyrtlaaqnivedmeqrgiwsihvycvdnilvkvadpr
figfciqkgadcgakvvektnptepvgvvcrvdgvyqvveyseislataqkrssdgrllf
nagnianhfftvpflrdvvnvyepqlqhhvaqkkipyvqgqlikpdkpngikmekfvfdi
fqfakkfvvyevlredefsplknadsqngkdnpttarhalmslhhcwvlnagghfideng
srlpaiprlkdandvpiqceisplisyageglesyvadkefhapliidengvhel