PDB entry 6z2c

View 6z2c on RCSB PDB site
Description: Engineered lipocalin C3A5 in complex with a transition state analog
Class: protein binding
Keywords: anticalin, beta-barrel, catalysis, diels-alder reaction, lcn2, lipocalin, ngal, protein engineering, transition state analog, protein binding
Deposited on 2020-05-15, released 2021-05-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-177)
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (51)
      • engineered mutation (67)
      • engineered mutation (69)
      • engineered mutation (71-72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (80)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (131)
      • engineered mutation (133)
      • expression tag (178-179)
    Domains in SCOPe 2.07: d6z2ca1, d6z2ca2
  • Chain 'B':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-177)
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (51)
      • engineered mutation (67)
      • engineered mutation (69)
      • engineered mutation (71-72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (80)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (131)
      • engineered mutation (133)
      • expression tag (178)
    Domains in SCOPe 2.07: d6z2cb1, d6z2cb2
  • Chain 'C':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-177)
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (51)
      • engineered mutation (67)
      • engineered mutation (69)
      • engineered mutation (71-72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (80)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (131)
      • engineered mutation (133)
    Domains in SCOPe 2.07: d6z2cc_
  • Heterogens: Q5E, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6z2cA (A:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvgmagngdlredkdpykmratiyelke
dksynvtwvwflpkkckyfintfvpgsqpgeftlgliksypgqtsllvrvvstnynqham
vffktviqnrerfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
wshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6z2cA (A:)
stsdlipapplskvplqqnfqdnqfhgkwyvvgmagngdlredkdpykmratiyelkedk
synvtwvwflpkkckyfintfvpgsqpgeftlgliksypgqtsllvrvvstnynqhamvf
fktviqnrerfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6z2cB (B:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvgmagngdlredkdpykmratiyelke
dksynvtwvwflpkkckyfintfvpgsqpgeftlgliksypgqtsllvrvvstnynqham
vffktviqnrerfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
wshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6z2cB (B:)
stsdlipapplskvplqqnfqdnqfhgkwyvvgmagngdlredkdpykmratiyelkedk
synvtwvwflpkkckyfintfvpgsqpgeftlgliksypgqtsllvrvvstnynqhamvf
fktviqnrerfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6z2cC (C:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvgmagngdlredkdpykmratiyelke
dksynvtwvwflpkkckyfintfvpgsqpgeftlgliksypgqtsllvrvvstnynqham
vffktviqnrerfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
wshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6z2cC (C:)
stsdlipapplskvplqqnfqdnqfhgkwyvvgmagngdlredkdpykmratiyelkedk
synvtwvwflpkkckyfintfvpgsqpgeftlgliksypgqtsllvrvvstnynqhamvf
fktviqnrerfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidg