PDB entry 6yw4

View 6yw4 on RCSB PDB site
Description: hif prolyl hydroxylase 2 (phd2/ egln1) in complex with n-oxalylglycine (nog) and a rapid-derived silent allosteric cyclic peptide 3c (14- mer)
Deposited on 2020-04-29, released 2020-12-30
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: XRAY
Resolution: 1.53 Å
R-factor: N/A
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Egl nine homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: EGLN1, C1orf12, PNAS-118, PNAS-137
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9GZT9
      • conflict (26)
      • conflict (223)
  • Chain 'B':
    Compound: PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER)
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6YW4 (0-13)
  • Heterogens: OGA, MN, SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6yw4A (A:)
gshmaspngqtkplpalklaleyivpamnkhgicvvddflgketgqqigdevralhdtgk
ftdgqlvsqksdsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsyking
rtkamvacypgngtgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfa
diepkfdrllffwsdrrnphevqpayatryaitvwyfdaderaaakvkyltge

    Sequence, based on observed residues (ATOM records):
    >6yw4A (A:)
kplpalklaleyivpamnkhgicvvddflgketgqqigdevralhdtgkftdgqdirgdk
itwiegkepgcetigllmssmddlirhcngklgsykingrtkamvacypgngtgyvrhvd
npngdgrcvtciyylnkdwdakvsggilrifpegkaqfadiepkfdrllffwsdrrnphe
vqpayatryaitvwyfdaderaaakvkylt

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6yw4B (B:)
xyvwltdtwvlsrt