PDB entry 6yvy

View 6yvy on RCSB PDB site
Description: FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Class: transferase
Keywords: protein tyrosine kinase, ATP binding, transferase, transferase-inhibitor complex
Deposited on 2020-04-28, released 2021-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yvya_
  • Chain 'B':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yvyb_
  • Chain 'C':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yvyc_
  • Chain 'D':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yvyd_
  • Heterogens: P1E, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yvyA (A:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yvyA (A:)
trdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqe
altmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqls
talayleskrfvhrdiaarnvlvssndcvklgdfglsrymgklpikwmapesinfrrfts
asdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcway
dpsrrprftelkaqlstileeekaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yvyB (B:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yvyB (B:)
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglslpikwmapesinfrrftsasdvwmfg
vcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprf
telkaqlstileeekaq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6yvyC (C:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yvyC (C:)
strdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflq
ealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayql
stalayleskrfvhrdiaarnvlvssndcvklgdflpikwmapesinfrrftsasdvwmf
gvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrpr
ftelkaqlstileeekaq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6yvyD (D:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yvyD (D:)
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfklpikwmapesinfrrftsasdvwmfgvc
mweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprfte
lkaqlstileeekaq