PDB entry 6yvx

View 6yvx on RCSB PDB site
Description: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic BB-287
Class: oxidoreductase
Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, DNA-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
Deposited on 2020-04-28, released 2020-12-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Egl nine homolog 1
  Species: Homo sapiens [TaxId:9606]
  Gene: EGLN1, C1orf12, PNAS-118, PNAS-137
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9GZT9
  Domains in SCOPe 2.08: d6yvxa_
• Heterogens: 2JP, MN, BCT, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >6yvxA (A:)
  gshmaspngqtkplpalklaleyivpcmnkhgicvvddflgketgqqigdevralhdtgk
  ftdgqlvsqksdsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsyking
  rtkamvacypgngtgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfa
  diepkfdrllffwsdrrnphevqpayatryaitvwyfdaderarakvkyltgekgvrvel
  nkpsdsvgkdvf
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6yvxA (A:)
  ngqtlpalklaleyivpcmnkhgicvvddflgketgqqigdevralhdtgkftdgqlvsq
  dsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsykingrtkamvacypg
  ngtgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfadiepkfdrllf
  fwsdrrnphevqpayatryaitvwyfdaderarakvkyltgrvel