PDB entry 6yv2

View 6yv2 on RCSB PDB site
Description: structure of the wnt deacylase notum in complex with a pyrrolidine-3-carboxylic acid fragment 598
Class: hydrolase
Keywords: Wnt, Wnt signalling, Frizzled, Fzd, Fragment screen, Notum, HYDROLASE
Deposited on 2020-04-27, released 2020-05-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-23, with a file datestamp of 2020-09-18.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Palmitoleoyl-protein carboxylesterase NOTUM
    Species: Homo sapiens [TaxId:9606]
    Gene: NOTUM, OK/SW-CL.30
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P988 (Start-373)
      • engineered mutation (252)
      • expression tag (374)
    Domains in SCOPe 2.08: d6yv2a1, d6yv2a2
  • Heterogens: PUE, NAG, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yv2A (A:)
etgsaqqlnedlrlhlllntsvtcndgspagyylkesrgsrrwllfleggwycfnrencd
srydtmrrlmssrdwprtrtgtgilssqpeenpywwnanmvfipycssdvwsgassksek
neyafmgaliiqevvrellgrglsgakvlllagssaggtgvllnvdrvaeqleklgypai
qvrgladsgwfldnkqyrhtdcvdtitcapteairrgirywngvvpercrrqfqegeewn
cffgykvyptlrspvfvvqwlfdeaqltvdnvhltgqpvqeglrlyiqnlgrelrhtlkd
vpasfapaclsheiiirshwtdvqvkgtslpralhcwdrslhdshkasktplkgcpvhlv
dscpwphcnpscptgtkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6yv2A (A:)
dlrlhlllntsvtcndgspagyylkesrgsrrwllfleggwycfnrencdsrydtmrrlm
ssrdwprtrtgtgilssqpeenpywwnanmvfipycssdvwsgassksekneyafmgali
iqevvrellgrglsgakvlllagssaggtgvllnvdrvaeqleklgypaiqvrgladsgw
fldnkqyrhtdcvdtitcapteairrgirywngvvpercrrqfqegeewncffgykvypt
lrspvfvvqwlfdeaqltvdnvhltgqpvqeglrlyiqnlgrelrhtlkdvpasfapacl
sheiiirshwtdvqvkgtslpralhcwdrslhtplkgcpvhlvdscpwphcnpscptg