PDB entry 6yt7

View 6yt7 on RCSB PDB site
Description: glycosylated knob/dummy-hole fc fragment
Class: immune system
Keywords: bispecific antibody fc engineering, knob-into-hole, format chain exchange, force, immune system
Deposited on 2020-04-24, released 2020-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-14, with a file datestamp of 2020-10-09.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Immunoglobulin gamma-1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DOX5
      • engineered mutation (145)
      • engineered mutation (149)
    Domains in SCOPe 2.08: d6yt7a1, d6yt7a2
  • Chain 'B':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • engineered mutation (145)
      • engineered mutation (147)
      • engineered mutation (186)
    Domains in SCOPe 2.08: d6yt7b1, d6yt7b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yt7A (A:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvytlppsrdeltknqvslwclvegfypsdiavewesngqpennykttppvlds
dgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgkggggshhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6yt7A (A:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsrd
eltknqvslwclvegfypsdiavewesngqpennykttppvldsdgsfflyskltvdksr
wqqgnvfscsvmhealhnhytqkslsls

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yt7B (B:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngqpennykttppvlds
dgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6yt7B (B:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrd
eltknqvslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksr
wqqgnvfscsvmhealhnhytqkslsls