PDB entry 6ysq

View 6ysq on RCSB PDB site
Description: the hc4nb8 complement inhibitory nanobody in complex with c4b
Deposited on 2020-04-23, released 2020-06-24
The last revision was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C4 Beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Complement C4 Beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Complement C4-A Alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C0L4 (0-End)
      • variant (256)
      • variant (444)
  • Chain 'D':
    Compound: Complement C4-A Alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C0L4 (0-End)
      • variant (256)
      • variant (444)
  • Chain 'E':
    Compound: Complement C4 gamma chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C0L5 (Start-290)
      • conflict (281)
      • conflict (283)
  • Chain 'F':
    Compound: Complement C4 gamma chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C0L5 (Start-290)
      • conflict (281)
      • conflict (283)
  • Chain 'G':
    Compound: hC4Nb8 nanobody
    Species: Escherichia coli [TaxId:562]
    Database cross-references and differences (RAF-indexed):
    • PDB 6YSQ (0-End)
  • Chain 'H':
    Compound: hC4Nb8 nanobody
    Species: Escherichia coli [TaxId:562]
    Database cross-references and differences (RAF-indexed):
    • PDB 6YSQ (0-End)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ysqA (A:)
kprlllfspsvvhlgvplsvgvqlqdvprgqvvkgsvflrnpsrnnvpcspkvdftlsse
rdfallslqvplkdakscglhqllrgpevqlvahspwlkdslsrttniqginllfssrrg
hlflqtdqpiynpgqrvryrvfaldqkmrpstdtitvmvenshglrvrkkevympssifq
ddfvipdisepgtwkisarfsdglesnsstqfevkkyvlpnfevkitpgkpyiltvpghl
demqldiqaryiygkpvqgvayvrfglldedgkktffrglesqtklvngqshislskaef
qdaleklnmgitdlqglrlyvaaaiiespggemeeaeltswyfvsspfsldlsktkrhlv
pgapfllqalvremsgspasgipvkvsatvsspgsvpevqdiqqntdgsgqvsipiiipq
tiselqlsvsagsphpaiarltvaappsggpgflsierpdsrpprvgdtlnlnlravgsg
atfshyyymilsrgqivfmnrepkrtltsvsvfvdhhlapsfyfvafyyhgdhpvanslr
vdvqagacegklelsvdgakqyrngesvklhletdslalvalgaldtalyaagskshkpl
nmgkvfeamnsydlgcgpgggdsalqvfqaaglafsdgdqwtlsrkrlscpkektt

    Sequence, based on observed residues (ATOM records):
    >6ysqA (A:)
kprlllfspsvvhlgvplsvgvqlqdvprgqvvkgsvflrnpsrnnvpcspkvdftlsse
rdfallslqvplkdakscglhqllrgpevqlvahspwlkdslsrttniqginllfssrrg
hlflqtdqpiynpgqrvryrvfaldqkmrpstdtitvmvenshglrvrkkevympssifq
ddfvipdisepgtwkisarfsdglesnsstqfevkkyvlpnfevkitpgkpyiltvpghl
demqldiqaryiygkpvqgvayvrfglldedgkktffrglesqtklvngqshislskaef
qdaleklnmgitdlqglrlyvaaaiiespggemeeaeltswyfvsspfsldlsktkrhlv
pgapfllqalvremsgspasgipvkvsatvsspgsvpevqdiqqntdgsgqvsipiiipq
tiselqlsvsagsphpaiarltvaappsggpgflsierpdsrpprvgdtlnlnlravgsg
atfshyyymilsrgqivfmnrepkrtltsvsvfvdhhlapsfyfvafyyhgdhpvanslr
vdvqagacegklelsvdgakqyrngesvklhletdslalvalgaldtalyaagskshkpl
nmgkvfeamnsydlgcgpgggdsalqvfqaaglafsdgdqwtlsrkrlscp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ysqB (B:)
kprlllfspsvvhlgvplsvgvqlqdvprgqvvkgsvflrnpsrnnvpcspkvdftlsse
rdfallslqvplkdakscglhqllrgpevqlvahspwlkdslsrttniqginllfssrrg
hlflqtdqpiynpgqrvryrvfaldqkmrpstdtitvmvenshglrvrkkevympssifq
ddfvipdisepgtwkisarfsdglesnsstqfevkkyvlpnfevkitpgkpyiltvpghl
demqldiqaryiygkpvqgvayvrfglldedgkktffrglesqtklvngqshislskaef
qdaleklnmgitdlqglrlyvaaaiiespggemeeaeltswyfvsspfsldlsktkrhlv
pgapfllqalvremsgspasgipvkvsatvsspgsvpevqdiqqntdgsgqvsipiiipq
tiselqlsvsagsphpaiarltvaappsggpgflsierpdsrpprvgdtlnlnlravgsg
atfshyyymilsrgqivfmnrepkrtltsvsvfvdhhlapsfyfvafyyhgdhpvanslr
vdvqagacegklelsvdgakqyrngesvklhletdslalvalgaldtalyaagskshkpl
nmgkvfeamnsydlgcgpgggdsalqvfqaaglafsdgdqwtlsrkrlscpkektt

    Sequence, based on observed residues (ATOM records):
    >6ysqB (B:)
kprlllfspsvvhlgvplsvgvqlqdvprgqvvkgsvflrnpsrnnvpcspkvdftlsse
rdfallslqvplkdakscglhqllrgpevqlvahspwlkdslsrttniqginllfssrrg
hlflqtdqpiynpgqrvryrvfaldqkmrpstdtitvmvenshglrvrkkevympssifq
ddfvipdisepgtwkisarfsdglesnsstqfevkkyvlpnfevkitpgkpyiltvpghl
demqldiqaryiygkpvqgvayvrfglldedgkktffrglesqtklvngqshislskaef
qdaleklnmgitdlqglrlyvaaaiiespggemeeaeltswyfvsspfsldlsktkrhlv
pgapfllqalvremsgspasgipvkvsatvsspgsvpevqdiqqntdgsgqvsipiiipq
tiselqlsvsagsphpaiarltvaappsggpgflsierpdsrpprvgdtlnlnlravgsg
atfshyyymilsrgqivfmnrepkrtltsvsvfvdhhlapsfyfvafyyhgdhpvanslr
vdvqagacegklelsvdgakqyrngesvklhletdslalvalgaldtalyaagskshkpl
nmgkvfeamnsydlgcgpgggdsalqvfqaaglafsdgdqwtlsrkrlscp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ysqC (C:)
aleilqeedlideddipvrsffpenwlwrvetvdrfqiltlwlpdslttweihglslskt
kglcvatpvqlrvfrefhlhlrlpmsvrrfeqlelrpvlynyldknltvsvhvspveglc
lagggglaqqvlvpagsarpvafsvvptaaaavslkvvargsfefpvgdavskvlqieke
gaihreelvyelnpldhrgrtleipgnsdpnmipdgdfnsyvrvtasdpldtlgsegals
pggvasllrlprgcgeetmiylaptlaasryldkteqwstlppetkdhavdliqkgymri
qqfrkadgsyaawlsrdsstwltafvlkvlslaqeqvggspeklqetsnwllsqqqadgs
fqdpcpvldrsmqgglvgndetvaltafvtialhhglavfqdegaeplkqrveasiskan
sflgekasagllgahaaaitayalsltkapvdllgvahnnlmamaqetgdnlywgsvtgs
qsnavsptpaprnpsdpmpqapalwiettayallhlllhegkaemadqasawltrqgsfq
ggfrstqdtvialdalsaywiashtteerglnvtlsstgrngfkshalqlnnrqirglee
elqfslgskinvkvggnskgtlkvlrtynvldmknttcqdlqievtvkghveytmeaned
yedyeydelpakddpdaplqpvtplqlfeg

    Sequence, based on observed residues (ATOM records):
    >6ysqC (C:)
aleilqeedlideddipvrsffpenwlwrvetvdrfqiltlwlpdslttweihglslskt
kglcvatpvqlrvfrefhlhlrlpmsvrrfeqlelrpvlynyldknltvsvhvspveglc
lagggglaqqvlvpagsarpvafsvvptaaaavslkvvargsfefpvgdavskvlqieke
gaihreelvyelnpldhrgrtleipgnsdpnmipdgdfnsyvrvtasdpldtlgsegals
pggvasllrlprgcgeetmiylaptlaasryldkteqwstlppetkdhavdliqkgymri
qqfrkadgsyaawlsrdsstwltafvlkvlslaqeqvggspeklqetsnwllsqqqadgs
fqdpcpvldrsmqgglvgndetvaltafvtialhhglavfqdegaeplkqrveasiskan
sflgekasagllgahaaaitayalsltkapvdllgvahnnlmamaqetgdnlywqapalw
iettayallhlllhegkaemadqasawltrqgsfqggfrstqdtvialdalsaywiasht
teerglnvtlsstgrngfkshalqlnnrqirgleeelqfslgskinvkvggnskgtlkvl
rtynvldmknttcqdlqievtvkghveytmean

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ysqD (D:)
aleilqeedlideddipvrsffpenwlwrvetvdrfqiltlwlpdslttweihglslskt
kglcvatpvqlrvfrefhlhlrlpmsvrrfeqlelrpvlynyldknltvsvhvspveglc
lagggglaqqvlvpagsarpvafsvvptaaaavslkvvargsfefpvgdavskvlqieke
gaihreelvyelnpldhrgrtleipgnsdpnmipdgdfnsyvrvtasdpldtlgsegals
pggvasllrlprgcgeetmiylaptlaasryldkteqwstlppetkdhavdliqkgymri
qqfrkadgsyaawlsrdsstwltafvlkvlslaqeqvggspeklqetsnwllsqqqadgs
fqdpcpvldrsmqgglvgndetvaltafvtialhhglavfqdegaeplkqrveasiskan
sflgekasagllgahaaaitayalsltkapvdllgvahnnlmamaqetgdnlywgsvtgs
qsnavsptpaprnpsdpmpqapalwiettayallhlllhegkaemadqasawltrqgsfq
ggfrstqdtvialdalsaywiashtteerglnvtlsstgrngfkshalqlnnrqirglee
elqfslgskinvkvggnskgtlkvlrtynvldmknttcqdlqievtvkghveytmeaned
yedyeydelpakddpdaplqpvtplqlfeg

    Sequence, based on observed residues (ATOM records):
    >6ysqD (D:)
aleilqeedlideddipvrsffpenwlwrvetvdrfqiltlwlpdslttweihglslskt
kglcvatpvqlrvfrefhlhlrlpmsvrrfeqlelrpvlynyldknltvsvhvspveglc
lagggglaqqvlvpagsarpvafsvvptaaaavslkvvargsfefpvgdavskvlqieke
gaihreelvyelnpldhrgrtleipgnsdpnmipdgdfnsyvrvtasdpldtlgsegals
pggvasllrlprgcgeetmiylaptlaasryldkteqwstlppetkdhavdliqkgymri
qqfrkadgsyaawlsrdsstwltafvlkvlslaqeqvggspeklqetsnwllsqqqadgs
fqdpcpvldrsmqgglvgndetvaltafvtialhhglavfqdegaeplkqrveasiskan
sflgekasagllgahaaaitayalsltkapvdllgvahnnlmamaqetgdnlywmpqapa
lwiettayallhlllhegkaemadqasawltrqgsfqggfrstqdtvialdalsaywias
htteerglnvtlsstgrngfkshalqlnnrqirgleeelqfslgskinvkvggnskgtlk
vlrtynvldmknttcqdlqievtvkghveytmean

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6ysqE (E:)
eapkvveeqesrvhytvciwrngkvglsgmaiadvtllsgfhalradlekltslsdryvs
hfetegphvllyfdsvptsrecvgfeavqevpvglvqpasatlydyynperrcsvfygap
sksrllatlcsaevcqcaegkcprqrralerglqdedgyrmkfacyyprveygfqvkvlr
edsraafrlfetkitqvlhftkdvkaaanqmrnflvrascrlrlepgkeylimgldgaty
dleghpqylldsnswieempserlcrstrqraacaqlndflnefgtqgcqv

    Sequence, based on observed residues (ATOM records):
    >6ysqE (E:)
qesrvhytvciwrngkvglsgmaiadvtllsgfhalradlekltslsdryvshfetegph
vllyfdsvptsrecvgfeavqevpvglvqpasatlydyynperrcsvfygapsksrllat
lcsaevcqcaegkcprqrralergyrmkfacyyprveygfqvkvlredsraafrlfetki
tqvlhftkdvkaaanqmrnflvrascrlrlepgkeylimgldgatydleghpqylldsns
wieempserlcrstrqraacaqlndflnefgtqgcqv

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6ysqF (F:)
eapkvveeqesrvhytvciwrngkvglsgmaiadvtllsgfhalradlekltslsdryvs
hfetegphvllyfdsvptsrecvgfeavqevpvglvqpasatlydyynperrcsvfygap
sksrllatlcsaevcqcaegkcprqrralerglqdedgyrmkfacyyprveygfqvkvlr
edsraafrlfetkitqvlhftkdvkaaanqmrnflvrascrlrlepgkeylimgldgaty
dleghpqylldsnswieempserlcrstrqraacaqlndflnefgtqgcqv

    Sequence, based on observed residues (ATOM records):
    >6ysqF (F:)
qesrvhytvciwrngkvglsgmaiadvtllsgfhalradlekltslsdryvshfetegph
vllyfdsvptsrecvgfeavqevpvglvqpasatlydyynperrcsvfygapsksrllat
lcsaevcqcaegkcprqrralergyrmkfacyyprveygfqvkvlredsraafrlfetki
tqvlhftkdvkaaanqmrnflvrascrlrlepgkeylimgldgatydleghpqylldsns
wieempserlcrstrqraacaqlndflnefgtqgcqv

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6ysqG (G:)
qvqlvesggglvqtgdslrlscaasgrtfsryamgwfrqapgkerelvaainwsggstyy
adfakgrftisrdnaknmlylrmsslkpedtavyycaaggpeveitraneydywgqgtqv
tvsslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6ysqG (G:)
qvqlvesggglvqtgdslrlscaasgrtfsryamgwfrqapgkerelvaainwsggstyy
adfakgrftisrdnaknmlylrmsslkpedtavyycaaggpeveitraneydywgqgtqv
tvss

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6ysqH (H:)
qvqlvesggglvqtgdslrlscaasgrtfsryamgwfrqapgkerelvaainwsggstyy
adfakgrftisrdnaknmlylrmsslkpedtavyycaaggpeveitraneydywgqgtqv
tvsslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6ysqH (H:)
qvqlvesggglvqtgdslrlscaasgrtfsryamgwfrqapgkerelvaainwsggstyy
adfakgrftisrdnaknmlylrmsslkpedtavyycaaggpeveitraneydywgqgtqv
tvss