PDB entry 6ysc

View 6ysc on RCSB PDB site
Description: glycosylated knob-hole/dummy fc fragment
Class: immune system
Keywords: bispecific antibody, fc engineering, knob-into-hole, force, format chain exchange, immune system
Deposited on 2020-04-22, released 2020-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-14, with a file datestamp of 2020-10-09.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Immunoglobulin gamma-1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DOX5
      • engineered mutation (133)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6ysca1, d6ysca2
  • Chain 'B':
    Compound: Immunoglobulin gamma-1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DOX5
      • engineered mutation (145)
      • engineered mutation (147)
      • engineered mutation (186)
    Domains in SCOPe 2.08: d6yscb1, d6yscb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yscA (A:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvlds
dgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6yscA (A:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppcrd
eltknqvslwclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksr
wqqgnvfscsvmhealhnhytqkslsl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yscB (B:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvytlppsrdkltknqvslscavkgfypsdiavewesngqpennykttppvlds
dgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgkggggshhhhhhhh
c

    Sequence, based on observed residues (ATOM records): (download) 
    >6yscB (B:)
gpsvflfppkpkdtlmisrtpevtcvvvdvkfnwyvdgvevhnaktkpreeqynstyrvv
svltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsknqvslsca
vkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvm
healhnhytqkslsls