PDB entry 6yqo

View 6yqo on RCSB PDB site
Description: Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12
Class: gene regulation
Keywords: bromodomain, BRD4(BD1), dual bromodomain HDAC inhibitor, structural genomics consortium, SGC, GENE REGULATION
Deposited on 2020-04-17, released 2020-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-18, with a file datestamp of 2020-11-13.
Experiment type: XRAY
Resolution: 1.07 Å
R-factor: N/A
AEROSPACI score: 0.86 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (2-126)
    • expression tag (0-1)
  Domains in SCOPe 2.08: d6yqoa1, d6yqoa2
• Heterogens: P8Q, EDO, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6yqoA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee