PDB entry 6yll

View 6yll on RCSB PDB site
Description: Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors
Class: transferase
Keywords: human mitogen activated protein kinase 6 (MAPK6), ERK3, inhibitor, TRANSFERASE
Deposited on 2020-04-07, released 2020-09-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 2.89 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK6, ERK3, PRKM6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16659
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ylla_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK6, ERK3, PRKM6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16659
      • engineered mutation (281)
  • Heterogens: OYB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yllA (A:)
mnihgfdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreiki
irrldhdnivkvfeilgpsgsqltddvgsltelnsvyivqeymetdlanvleqgplleeh
arlfmyqllrglkyihsanvlhrdlkpanlfintedlvlkigdfglarimdphyshkghl
seglvtkwyrsprlllspnnytkaidmwaagcifaemltgktlfagaheleqmqlilesi
pvvheedrqellsvipvyirndmtephkpltqllpgisreavdfleqiltfspmdrltae
ealshpymsiysfpmdepi

    Sequence, based on observed residues (ATOM records): (download) 
    >6yllA (A:)
fdlgsrymdlkplggnglvfsavdndcdkrvaikkivltdpqsvkhalreikiirrldhd
nivkvfeilgpsgsqltdtelnsvyivqeymetdlanvleqgplleeharlfmyqllrgl
kyihsanvlhrdlkpanlfintedlvlkigdfglarimhlseglvtkwyrsprlllspnn
ytkaidmwaagcifaemltgktlfagaheleqmqlilesipvvheedrqellsvipvyir
ndmtephkpltqllpgisreavdfleqiltfspmdrltaeealshpymsiysf

  • Chain 'B':
    No sequence available.