PDB entry 6ylk

View 6ylk on RCSB PDB site
Description: Cdk2(F80C) with Covalent Adduct TK22 at F80C
Class: transferase
Keywords: Covalent inhibitor, Cysteine modification, Kinase, Allosteric inhibitor, TRANSFERASE
Deposited on 2020-04-07, released 2020-07-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-16, with a file datestamp of 2020-12-11.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (5-302)
      • expression tag (0-4)
      • engineered mutation (84)
      • engineered mutation (181)
    Domains in SCOPe 2.08: d6ylka1, d6ylka2
  • Heterogens: OY2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ylkA (A:)
gplgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisll
kelnhpnivklldvihtenklylvceflhqdlkkfmdasaltgiplpliksylfqllqgl
afchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeill
gakyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpd
ykpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph
lrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6ylkA (A:)
gplgsmenfqkvekigegtygvvykarnkltgevvalkkirlstaireisllkelnhpni
vklldvihtenklylvceflhqdlkkfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgakyysta
vdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkw
arqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl