PDB entry 6yky

View 6yky on RCSB PDB site
Description: Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors
Class: transferase
Keywords: Mitogen-activated protein kinase 6, TRANSFERASE
Deposited on 2020-04-06, released 2020-09-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK6, ERK3, PRKM6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16659
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ykya_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK6, ERK3, PRKM6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16659
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ykyb_
  • Chain 'C':
    Compound: Mitogen-activated protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK6, ERK3, PRKM6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16659
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ykyc_
  • Chain 'D':
    Compound: Mitogen-activated protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK6, ERK3, PRKM6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16659
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ykyd_
  • Heterogens: OWQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ykyA (A:)
mnihgfdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreiki
irrldhdnivkvfeilgpsgsqltddvgsltelnsvyivqeymetdlanvleqgplleeh
arlfmyqllrglkyihsanvlhrdlkpanlfintedlvlkigdfglarimdphyshkghl
seglvtkwyrsprlllspnnytkaidmwaagcifaemltgktlfagaheleqmqlilesi
pvvheedrqellsvipvyirndmtephkpltqllpgisreavdfleqiltfspmdrltae
ealshpymsiysfpmdepi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ykyA (A:)
srymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreikiirrldhdni
vkvfeilgpsgsqsvyivqeymetdlanvleqgplleeharlfmyqllrglkyihsanvl
hrdlkpanlfintedlvlkigdfglarimlseglvtkwyrsprlllspnnytkaidmwaa
gcifaemltgktlfagaheleqmqlilesipvvheedrqellsvipvyirndmtephkpl
tqllpgisreavdfleqiltfspmdrltaeealshpymsiy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ykyB (B:)
mnihgfdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreiki
irrldhdnivkvfeilgpsgsqltddvgsltelnsvyivqeymetdlanvleqgplleeh
arlfmyqllrglkyihsanvlhrdlkpanlfintedlvlkigdfglarimdphyshkghl
seglvtkwyrsprlllspnnytkaidmwaagcifaemltgktlfagaheleqmqlilesi
pvvheedrqellsvipvyirndmtephkpltqllpgisreavdfleqiltfspmdrltae
ealshpymsiysfpmdepi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ykyB (B:)
lgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreikiirrldhd
nivkvfeilgpsgsqlttelnsvyivqeymetdlanvleqgplleeharlfmyqllrglk
yihsanvlhrdlkpanlfintedlvlkigdfglarimdphlseglvtkwyrsprlllspn
nytkaidmwaagcifaemltgktlfagaheleqmqlilesipvvheedrqellsvipvmt
ephkpltqllpgisreavdfleqiltfspmdrltaeealshpymsiysf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6ykyC (C:)
mnihgfdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreiki
irrldhdnivkvfeilgpsgsqltddvgsltelnsvyivqeymetdlanvleqgplleeh
arlfmyqllrglkyihsanvlhrdlkpanlfintedlvlkigdfglarimdphyshkghl
seglvtkwyrsprlllspnnytkaidmwaagcifaemltgktlfagaheleqmqlilesi
pvvheedrqellsvipvyirndmtephkpltqllpgisreavdfleqiltfspmdrltae
ealshpymsiysfpmdepi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ykyC (C:)
gfdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivldpqsvkhalreikiirrld
hdnivkvfeilgpsgsqlsvyivqeymetdlanvleqgplleeharlfmyqllrglkyih
sanvlhrdlkpanlfintedlvlkigdfglarimlseglvtkwyrsprlllspnnytkai
dmwaagcifaemltgktlfagaheleqmqlilesipvvheedrqellsviprndmtephk
pltqllpgisreavdfleqiltfspmdrltaeealshpymsiy

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ykyD (D:)
mnihgfdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreiki
irrldhdnivkvfeilgpsgsqltddvgsltelnsvyivqeymetdlanvleqgplleeh
arlfmyqllrglkyihsanvlhrdlkpanlfintedlvlkigdfglarimdphyshkghl
seglvtkwyrsprlllspnnytkaidmwaagcifaemltgktlfagaheleqmqlilesi
pvvheedrqellsvipvyirndmtephkpltqllpgisreavdfleqiltfspmdrltae
ealshpymsiysfpmdepi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ykyD (D:)
fdlgsrymdlkplgcggnglvfsavdndcdkrvaikkivltdpqsvkhalreikiirrld
hdnivkvfeilgpsgsqltddvgsltelnsvyivqeymetdlanvleqgplleeharlfm
yqllrglkyihsanvlhrdlkpanlfintedlvlkigdfglarimdphyshkghlseglv
tkwyrsprlllspnnytkaidmwaagcifaemltgktlfagaheleqmqlilesipvvhe
edrqellsviptephkpltqllpgisreavdfleqiltfspmdrltaeealshpymsiys
f