PDB entry 6yjm

View 6yjm on RCSB PDB site
Description: Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with the Inhibitor GLPG1972
Class: hydrolase
Keywords: zinc metalloproteinase, aggrecanase, HYDROLASE
Deposited on 2020-04-03, released 2021-04-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-14, with a file datestamp of 2021-04-09.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: A disintegrin and metalloproteinase with thrombospondin motifs 5
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAMTS5, ADAMTS11, ADMP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UNA0 (2-219)
      • engineered mutation (20)
      • expression tag (220-221)
    Domains in SCOPe 2.08: d6yjma1, d6yjma2
  • Chain 'B':
    Compound: A disintegrin and metalloproteinase with thrombospondin motifs 5
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAMTS5, ADAMTS11, ADMP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UNA0
      • engineered mutation (20)
    Domains in SCOPe 2.08: d6yjmb_
  • Heterogens: OU5, ZN, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yjmA (A:)
sisrarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvvvl
gdkdkslevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtlgm
advgticsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlmss
iltsidaskpwskctsatiteflddghgnclldlprkqilvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yjmA (A:)
srarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvvvlgk
slevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtlgmadvgt
icsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlmssiltsi
daskpwskctsatiteflddghgnclldlprkqilvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yjmB (B:)
sisrarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvvvl
gdkdkslevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtlgm
advgticsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlmss
iltsidaskpwskctsatiteflddghgnclldlprkqilvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yjmB (B:)
rarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvvvlksl
evsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtlgmadvgtic
sperscavieddglhaaftvaheighllglshddskfceetfgstedkrlmssiltsida
skpwskctsatiteflddghgnclldlprkqi