PDB entry 6yg6

View 6yg6 on RCSB PDB site
Description: Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor TL10-105
Class: transferase
Keywords: kinase, kinase inhibitor, MKK7, MEK7, MAP2K7, MAP2K, MEK, JNK signaling, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2020-03-27, released 2020-08-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-28, with a file datestamp of 2020-10-23.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yg6a_
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yg6b_
  • Heterogens: OQ8, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yg6A (A:)
smkqtgyltiggqryqaeindlenlgemgsgtcgqvwkmrfrktghviavkqmrrsgnke
enkrilmdldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperi
lgkmtvaivkalyylkekhgvihrdvkpsnilldergqiklcdfgisgrlvddkakdrsa
gcaaymaperidppdptkpdydiradvwslgislvelatgqfpykncktdfevltkvlqe
eppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdvaswfkdvm
aktespr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yg6A (A:)
tgyltiggqryqaeindlenlgemgsgqvwkmrfrktghviavkqmrrsgnkeenkrilm
dldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtva
ivkalyylkekhgvihrdvkpsnilldergqiklcdfgagcaaymaperidppdptkpdy
diradvwslgislvelatgqfpykncktdfevltkvlqeeppllpghmgfsgdfqsfvkd
cltkdhrkrpkynkllehsfikryetlevdvaswfkdvmaktes

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yg6B (B:)
smkqtgyltiggqryqaeindlenlgemgsgtcgqvwkmrfrktghviavkqmrrsgnke
enkrilmdldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperi
lgkmtvaivkalyylkekhgvihrdvkpsnilldergqiklcdfgisgrlvddkakdrsa
gcaaymaperidppdptkpdydiradvwslgislvelatgqfpykncktdfevltkvlqe
eppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdvaswfkdvm
aktespr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yg6B (B:)
gyltiggqryqaeindlenlgemggqvwkmrfrktghviavkqmrrsgnkeenkrilmdl
dvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvaiv
kalyylkekhgvihrdvkpsnilldergqiklcdfggcaaymaperidppdptkpdydir
advwslgislvelatgqfpykncktdfevltkvlqeeppllpghmgfsgdfqsfvkdclt
kdhrkrpkynkllehsfikryetlevdvaswfkdvmaktes