PDB entry 6yg1

View 6yg1 on RCSB PDB site
Description: Crystal structure of MKK7 (MAP2K7) in an active state, allosterically triggered by the N-terminal helix
Class: transferase
Keywords: kinase, kinase inhibitor, MKK7, MEK7, MAP2K7, MAP2K, MEK, JNK signaling, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE, Scottish Structural Proteomics Facility, SSPF
Deposited on 2020-03-27, released 2020-08-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-28, with a file datestamp of 2020-10-23.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14733
      • engineered mutation (213)
      • engineered mutation (217)
    Domains in SCOPe 2.08: d6yg1a_
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14733
      • engineered mutation (213)
      • engineered mutation (217)
    Domains in SCOPe 2.08: d6yg1b_
  • Chain 'C':
    Compound: Dual specificity mitogen-activated protein kinase kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14733 (Start-347)
      • engineered mutation (213)
      • engineered mutation (217)
    Domains in SCOPe 2.08: d6yg1c_
  • Heterogens: NA, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yg1A (A:)
smsspqhptpparprhmlglpstlftprsmesieidqklqeimkqtgyltiggqryqaei
ndlenlgemgsgtcgqvwkmrfrktghviavkqmrrsgnkeenkrilmdldvvlkshdcp
yivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvaivkalyylkekh
gvihrdvkpsnilldergqiklcdfgisgrlvddkakdrsagcaaymaperidppdptkp
dydiradvwslgislvelatgqfpykncktdfevltkvlqeeppllpghmgfsgdfqsfv
kdcltkdhrkrpkynkllehsfikryetlevdvaswfkdvmaktespr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yg1A (A:)
smesieidqklqeimkqtgyltiggqryqaeindlenlgemgqvwkmrfrktghviavkq
mrrsgnkeenkrilmdldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrm
qgpiperilgkmtvaivkalyylkekhgvihrdvkpsnilldergqiklcdfgisgrlvd
dkakdrsagcaaymaperidppdptkpdydiradvwslgislvelatgqfpykncktdfe
vltkvlqeeppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdv
aswfkdvmaktesp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yg1B (B:)
smsspqhptpparprhmlglpstlftprsmesieidqklqeimkqtgyltiggqryqaei
ndlenlgemgsgtcgqvwkmrfrktghviavkqmrrsgnkeenkrilmdldvvlkshdcp
yivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvaivkalyylkekh
gvihrdvkpsnilldergqiklcdfgisgrlvddkakdrsagcaaymaperidppdptkp
dydiradvwslgislvelatgqfpykncktdfevltkvlqeeppllpghmgfsgdfqsfv
kdcltkdhrkrpkynkllehsfikryetlevdvaswfkdvmaktespr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yg1B (B:)
dqklqeimkqtgyltiggqryqaeindlenlgemgqvwkmrfrktghviavkqmrrsgnk
eenkrilmdldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiper
ilgkmtvaivkalyylkekhgvihrdvkpsnilldergqiklcdfgisgrlvddkakdrs
agcaaymaperidppdptkpdydiradvwslgislvelatgqfpykncktdfevltkvlq
eeppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdvaswfkdv
maktesp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6yg1C (C:)
smsspqhptpparprhmlglpstlftprsmesieidqklqeimkqtgyltiggqryqaei
ndlenlgemgsgtcgqvwkmrfrktghviavkqmrrsgnkeenkrilmdldvvlkshdcp
yivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvaivkalyylkekh
gvihrdvkpsnilldergqiklcdfgisgrlvddkakdrsagcaaymaperidppdptkp
dydiradvwslgislvelatgqfpykncktdfevltkvlqeeppllpghmgfsgdfqsfv
kdcltkdhrkrpkynkllehsfikryetlevdvaswfkdvmaktespr

    Sequence, based on observed residues (ATOM records): (download) 
    >6yg1C (C:)
smesieidqklqeimkqtgyltiggqryqaeindlenlgemgqvwkmrfrktghviavkq
mrrsgnkeenkrilmdldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrm
qgpiperilgkmtvaivkalyylkekhgvihrdvkpsnilldergqiklcdfgisgrlvd
dkakdrsagcaaymaperidppdptkpdydiradvwslgislvelatgqfpykncktdfe
vltkvlqeeppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdv
aswfkdvmaktespr