PDB entry 6yaf

View 6yaf on RCSB PDB site
Description: ap2 on a membrane containing tyrosine-based cargo peptide
Deposited on 2020-03-12, released 2020-07-29
The last revision was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: EM
Resolution: 9.1 Å
R-factor: N/A
AEROSPACI score: -0.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ap-2 complex subunit alpha-2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Ap2a2, Adtab
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18484
      • insertion (271)
  • Chain 'B':
    Compound: ap-2 complex subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: AP2B1, ADTB2, CLAPB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: ap-2 complex subunit mu
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Ap2m1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84092 (0-445)
      • insertion (236-246)
  • Chain 'P':
    Compound: Tyrosine type cargo signal derived from TGN38
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6YAF (Start-15)
  • Chain 'S':
    Compound: ap-2 complex subunit sigma
    Species: Mus musculus [TaxId:10090]
    Gene: Ap2s1, Ap17, Claps2
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6yafA (A:)
mpavskgdgmrglavfisdirnckskeaeikrinkelanirskfkgdkaldgyskkkyvc
kllfifllghdidfghmeavnllssnrytekqigylfisvlvnsnselirlinnaikndl
asrnptfmglalhcianvgsremaeafageipkilvagdtmdsvkqsaalcllrlyrtsp
dlvpmgdwtsrvvhllndqhlgvvtaatslittlaqknpeefktsvslavsrlsrivtsa
stdlqdytyyfvpapwlsvkllrllqcypppedpavrgrltecletilnkaqeppkskkv
qhsnaknavlfeaisliihhdsepnllvracnqlgqflqhretnlrylalesmctlasse
fsheavkthietvinalkterdvsvrqravdllyamcdrsnaqqivaemlsyletadysi
reeivlkvailaekyavdytwyvdtilnliriagdyvseevwyrviqivinrddvqgyaa
ktvfealqapachenlvkvggyilgefgnliagdprsspliqfnllhskfhlcsvptral
llstyikfvnlfpevkatiqdvlrsdsqlknadvelqqraveylrlstvastdilatvle
emppfperessilaklkkkkggsglvpr

    Sequence, based on observed residues (ATOM records):
    >6yafA (A:)
gmrglavfisdirnckskeaeikrinkelanirskfkgdkaldgyskkkyvckllfifll
ghdidfghmeavnllssnrytekqigylfisvlvnsnselirlinnaikndlasrnptfm
glalhcianvgsremaeafageipkilvagdtmdsvkqsaalcllrlyrtspdlvpmgdw
tsrvvhllndqhlgvvtaatslittlaqknpeefktsvslavsrlsrivtsastdlqdyt
yyfvpapwlsvkllrllqcypppedpavrgrltecletilnkaqeppkskkvqhsnakna
vlfeaisliihhdsepnllvracnqlgqflqhretnlrylalesmctlassefsheavkt
hietvinalkterdvsvrqravdllyamcdrsnaqqivaemlsyletadysireeivlkv
ailaekyavdytwyvdtilnliriagdyvseevwyrviqivinrddvqgyaaktvfealq
apachenlvkvggyilgefgnliagdprsspliqfnllhskfhlcsvptralllstyikf
vnlfpevkatiqdvlrsdsqlknadvelqqraveylrlstvastdilatvleemppfper
essilaklkkkkg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6yafB (B:)
mhhhhhhmtdskyfttnkkgeifelkaelnnekkekrkeavkkviaamtvgkdvsslfpd
vvncmqtdnlelkklvylylmnyaksqpdmaimavnsfvkdcedpnpliralavrtmgci
rvdkiteylceplrkclkdedpyvrktaavcvaklhdinaqmvedqgfldslrdliadsn
pmvvanavaalseiseshpnsnlldlnpqninklltalnectewgqifildclsnynpkd
dreaqsicervtprlshansavvlsavkvlmkflellpkdsdyynmllkklapplvtlls
gepevqyvalrninlivqkrpeilkqeikvffvkyndpiyvklekldimirlasqaniaq
vlaelkeyatevdvdfvrkavraigrcaikveqsaercvstlldliqtkvnyvvqeaivv
irdifrkypnkyesiiatlcenldsldepdaraamiwivgeyaeridnadellesflegf
hdestqvqltlltaivklflkkpsetqelvqqvlslatqdsdnpdlrdrgyiywrllstd
pvtakevvlsekpliseetdlieptlldelichigslasvyhkppnafvegshgihrkhl
pihhgstdagdspvgtttatnleqpqvipsqgdllgdllnldlgppvnvpqvssmqmgav
dllgggldslvgqsfipssvpatfapsptpavvssglndlfelstgigmapggyvapkav
wlpavkakgleisgtfthrqghiymemnftnkalqhmtdfaiqfnknsfgvipstplaih
tplmpnqsidvslplntlgpvmkmeplnnlqvavknnidvfyfscliplnvlfvedgkme
rqvflatwkdipnenelqfqikechlnadtvssklqnnnvytiakrnvegqdmlyqslkl
tngiwilaelriqpgnpnytlslkcrapevsqyiyqvydsilkn

    Sequence, based on observed residues (ATOM records):
    >6yafB (B:)
skyfttnkkgeifelkaelnnekkekrkeavkkviaamtvgkdvsslfpdvvncmqtdnl
elkklvylylmnyaksqpdmaimavnsfvkdcedpnpliralavrtmgcirvdkiteylc
eplrkclkdedpyvrktaavcvaklhdinaqmvedqgfldslrdliadsnpmvvanavaa
lseiseshpnsnlldlnpqninklltalnectewgqifildclsnynpkddreaqsicer
vtprlshansavvlsavkvlmkflellpkdsdyynmllkklapplvtllsgepevqyval
rninlivqkrpeilkqeikvffvkyndpiyvklekldimirlasqaniaqvlaelkeyat
evdvdfvrkavraigrcaikveqsaercvstlldliqtkvnyvvqeaivvirdifrkypn
kyesiiatlcenldsldepdaraamiwivgeyaeridnadellesflegfhdestqvqlt
lltaivklflkkpsetqelvqqvlslatqdsdnpdlrdrgyiywrllstdpvtakevvls
ekpliseetdlieptlldelichigslasvyhkppnafv

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6yafM (M:)
migglfiynhkgevlisrvyrddigrnavdafrvnviharqqvrspvtniartsffhvkr
sniwlaavtkqnvnaamvfeflykmcdvmaayfgkiseeniknnfvliyelldeildfgy
pqnsetgalktfitqqgiksqhqtkeeqsqitsqvtgqigwrregikyrrnelfldvles
vnllmspqgqvlsahvsgrvvmksylsgmpeckfgmndkiviekqgkgtadetsksmeqk
liseedlgkqsiaiddctfhqcvrlskfdsersisfippdgefelmryrttkdiilpfrv
iplvrevgrtklevkvviksnfkpsllaqkievriptplntsgvqvicmkgkakykasen
aivwkikrmagmkesqisaeiellptndkkkwarppismnfevpfapsglkvrylkvfep
klnysdhdvikwvryigrsgiyetrc

    Sequence, based on observed residues (ATOM records):
    >6yafM (M:)
migglfiynhkgevlisrvyrddigrnavdafrvnviharqqvrspvtniartsffhvkr
sniwlaavtkqnvnaamvfeflykmcdvmaayfgkiseeniknnfvliyelldeildfgy
pqnsetgalktfitqhqtkeeqsqitsqvtgqigwrregikyrrnelfldvlesvnllms
pqgqvlsahvsgrvvmksylsgmpeckfgmndkiviesmeqkliseedlgkqsiaiddct
fhqcvrlskfdsersisfippdgefelmryrttkdiilpfrviplvrevgrtklevkvvi
ksnfkpsllaqkievriptplntsgvqvicmkgkakykasenaivwkikrmagmkesqis
aeiellptndkkkwarppismnfevpfapsglkvrylkvfepklnysdhdvikwvryigr
sgiyetrc

  • Chain 'P':
    Sequence, based on SEQRES records:
    >6yafP (P:)
ckvtrrpkasdyqrln

    Sequence, based on observed residues (ATOM records):
    >6yafP (P:)
dyqrln

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records:
    >6yafS (S:)
mirfiliqnragktrlakwymqfdddekqklieevhavvtvrdakhtnfvefrnfkiiyr
ryaglyfcicvdvndnnlayleaihnfvevlneyfhnvceldlvfnfykvytvvdemfla
geiretsqtkvlkqllmlqsle