PDB entry 6y6c

View 6y6c on RCSB PDB site
Description: TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4)
Class: immune system
Keywords: scFv, complex, receptor, Alzheimer's, IMMUNE SYSTEM
Deposited on 2020-02-26, released 2021-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Triggering receptor expressed on myeloid cells 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TREM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NZC2 (25-180)
      • expression tag (0-24)
      • expression tag (181-201)
  • Chain 'B':
    Compound: Triggering receptor expressed on myeloid cells 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TREM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NZC2 (25-180)
      • expression tag (0-24)
      • expression tag (181-201)
  • Chain 'C':
    Compound: Single chain variable
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Y6C (0-244)
    Domains in SCOPe 2.08: d6y6cc1, d6y6cc2
  • Chain 'D':
    Compound: Single chain variable
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Y6C (0-244)
    Domains in SCOPe 2.08: d6y6cd1, d6y6cd2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6y6cC (C:)
smevqllesggglvqpggslrlscaasgftfsyyymgwvrqapgkglewvsgispssgyt
yyadsvkgrftisrdnskntlylqmnslraedtavyycaryyygyyyshmdywgqgtlvt
vssggggsggggsggggsdiqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgk
apklliyaasslqsgvpsrfsgsgsgtdftltisslqpedfatyycqqsrsglhtfgqgt
kleik

    Sequence, based on observed residues (ATOM records): (download) 
    >6y6cC (C:)
evqllesggglvqpggslrlscaasgftfsyyymgwvrqapgkglewvsgispssgytyy
adsvkgrftisrdnskntlylqmnslraedtavyycaryyygyyyshmdywgqgtlvtvs
sdiqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapklliyaasslqsgvp
srfsgsgsgtdftltisslqpedfatyycqqsrsglhtfgqgtkleik

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6y6cD (D:)
smevqllesggglvqpggslrlscaasgftfsyyymgwvrqapgkglewvsgispssgyt
yyadsvkgrftisrdnskntlylqmnslraedtavyycaryyygyyyshmdywgqgtlvt
vssggggsggggsggggsdiqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgk
apklliyaasslqsgvpsrfsgsgsgtdftltisslqpedfatyycqqsrsglhtfgqgt
kleik

    Sequence, based on observed residues (ATOM records): (download) 
    >6y6cD (D:)
evqllesggglvqpggslrlscaasgftfsyyymgwvrqapgkglewvsgispssgytyy
adsvkgrftisrdnskntlylqmnslraedtavyycaryyygyyyshmdywgqgtlvtvs
ssdiqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapklliyaasslqsgv
psrfsgsgsgtdftltisslqpedfatyycqqsrsglhtfgqgtkleik