PDB entry 6xz9

View 6xz9 on RCSB PDB site
Description: Structure of aldosterone synthase (CYP11B2) in complex with 5-chloro-3,3-dimethyl-2-[5-[1-(1-methylpyrazole-4-carbonyl)azetidin-3-yl]oxy-3-pyridyl]isoindolin-1-one
Class: oxidoreductase
Keywords: cytochrome p450, cyp11b2, aldosterone synthase, oxidoreductase
Deposited on 2020-02-03, released 2020-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-22, with a file datestamp of 2020-07-17.
Experiment type: XRAY
Resolution: 2.77 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 11B2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP11B2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xz9a_
  • Chain 'B':
    Compound: Cytochrome P450 11B2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP11B2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19099 (Start-479)
      • expression tag (480)
    Domains in SCOPe 2.08: d6xz9b1, d6xz9b2
  • Chain 'C':
    Compound: Cytochrome P450 11B2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP11B2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xz9c_
  • Heterogens: O4W, HEC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xz9A (A:)
matkaaraprtvlpfeampqhpgnrwlrllqiwreqgyehlhlemhqtfqelgpifrynl
ggprmvcvmlpedveklqqvdslhpcrmilepwvayrqhrghkcgvfllngpewrfnrlr
lnpdvlspkavqrflpmvdavardfsqalkkkvlqnargsltldvqpsifhytieasnla
lfgerlglvghspssaslnflhalevmfkstvqlmfmprslsrwispkvwkehfeawdci
fqygdnciqkiyqelafnrpqhytgivaelllkaelsleaikansmeltagsvdttafpl
lmtlfelarnpdvqqilrqeslaaaasisehpqkattelpllraalketlrlypvglfle
rvvssdlvlqnyhipagtlvqvflyslgrnaalfprperynpqrwldirgsgrnfhhvpf
gfgmrqclgrrlaeaemllllhhvlkhflvetltqedikmvysfilrpgtsplltfrain
ggrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xz9A (A:)
tvlpfeampqhpgnrwlrllqiwreqgyehlhlemhqtfqelgpifrynlggprmvcvml
pedveklqqvdslhpcrmilepwvayrqhrghkcgvfllngpewrfnrlrlnpdvlspka
vqrflpmvdavardfsqalkkkvlqnargsltldvqpsifhytieasnlalfgerlglvg
hspssaslnflhalevmfkstvqlmfmprslsrwispkvwkehfeawdcifqygdnciqk
iyqelafnrpqhytgivaelllkaelsleaikansmeltagsvdttafpllmtlfelarn
pdvqqilrqeslaaaasisehpqkattelpllraalketlrlypvglflervvssdlvlq
nyhipagtlvqvflyslgrnaalfprperynpqrwldnfhhvpfgfgmrqclgrrlaeae
mllllhhvlkhflvetltqedikmvysfilrpgtsplltfrain

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xz9B (B:)
matkaaraprtvlpfeampqhpgnrwlrllqiwreqgyehlhlemhqtfqelgpifrynl
ggprmvcvmlpedveklqqvdslhpcrmilepwvayrqhrghkcgvfllngpewrfnrlr
lnpdvlspkavqrflpmvdavardfsqalkkkvlqnargsltldvqpsifhytieasnla
lfgerlglvghspssaslnflhalevmfkstvqlmfmprslsrwispkvwkehfeawdci
fqygdnciqkiyqelafnrpqhytgivaelllkaelsleaikansmeltagsvdttafpl
lmtlfelarnpdvqqilrqeslaaaasisehpqkattelpllraalketlrlypvglfle
rvvssdlvlqnyhipagtlvqvflyslgrnaalfprperynpqrwldirgsgrnfhhvpf
gfgmrqclgrrlaeaemllllhhvlkhflvetltqedikmvysfilrpgtsplltfrain
ggrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xz9B (B:)
prtvlpfeampqhpgnrwlrllqiwreqgyehlhlemhqtfqelgpifrynlggprmvcv
mlpedveklqqvdslhpcrmilepwvayrqhrghkcgvfllngpewrfnrlrlnpdvlsp
kavqrflpmvdavardfsqalkkkvlqnargsltldvqpsifhytieasnlalfgerlgl
vghspssaslnflhalevmfkstvqlmfmprslsrwispkvwkehfeawdcifqygdnci
qkiyqelafnrpqhytgivaelllkaelsleaikansmeltagsvdttafpllmtlfela
rnpdvqqilrqeslaaaasisehpqkattelpllraalketlrlypvglflervvssdlv
lqnyhipagtlvqvflyslgrnaalfprperynpqrwldirgsgrnfhhvpfgfgmrqcl
grrlaeaemllllhhvlkhflvetltqedikmvysfilrpgtsplltfraing

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xz9C (C:)
matkaaraprtvlpfeampqhpgnrwlrllqiwreqgyehlhlemhqtfqelgpifrynl
ggprmvcvmlpedveklqqvdslhpcrmilepwvayrqhrghkcgvfllngpewrfnrlr
lnpdvlspkavqrflpmvdavardfsqalkkkvlqnargsltldvqpsifhytieasnla
lfgerlglvghspssaslnflhalevmfkstvqlmfmprslsrwispkvwkehfeawdci
fqygdnciqkiyqelafnrpqhytgivaelllkaelsleaikansmeltagsvdttafpl
lmtlfelarnpdvqqilrqeslaaaasisehpqkattelpllraalketlrlypvglfle
rvvssdlvlqnyhipagtlvqvflyslgrnaalfprperynpqrwldirgsgrnfhhvpf
gfgmrqclgrrlaeaemllllhhvlkhflvetltqedikmvysfilrpgtsplltfrain
ggrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xz9C (C:)
tvlpfeampqhpgnrwlrllqiwreqgyehlhlemhqtfqelgpifrynlggprmvcvml
pedveklqqvdslhpcrmilepwvayrqhrghkcgvfllngpewrfnrlrlnpdvlspka
vqrflpmvdavardfsqalkkkvlqnargsltldvqpsifhytieasnlalfgerlglvg
hspssaslnflhalevmfkstvqlmfmprslsrwispkvwkehfeawdcifqygdnciqk
iyqelafnrpqhytgivaelllkaelsleaikansmeltagsvdttafpllmtlfelarn
pdvqqilrqeslaaaasisehpqkattelpllraalketlrlypvglflervvssdlvlq
nyhipagtlvqvflyslgrnaalfprperynpqrwldirnfhhvpfgfgmrqclgrrlae
aemllllhhvlkhflvetltqedikmvysfilrpgtsplltfrain