PDB entry 6xxs

View 6xxs on RCSB PDB site
Description: crystal structure of an ncor1bbd2-bcl6btb chimera in complex with the ncor1 bbd1 corepressor peptide.
Deposited on 2020-01-28, released 2020-12-02
The last revision was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: B-cell lymphoma 6 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL6, BCL5, LAZ3, ZBTB27, ZNF51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41182 (11-End)
      • expression tag (3-10)
      • engineered mutation (13)
      • engineered mutation (72)
      • engineered mutation (89)
  • Chain 'B':
    Compound: B-cell lymphoma 6 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL6, BCL5, LAZ3, ZBTB27, ZNF51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41182 (11-End)
      • expression tag (1-10)
      • engineered mutation (13)
      • engineered mutation (72)
      • engineered mutation (89)
  • Chain 'C':
    Compound: Nuclear receptor corepressor 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Nuclear receptor corepressor 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: B-cell lymphoma 6 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL6, BCL5, LAZ3, ZBTB27, ZNF51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41182 (2-End)
      • engineered mutation (4)
      • engineered mutation (63)
      • engineered mutation (80)
  • Chain 'F':
    Compound: B-cell lymphoma 6 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL6, BCL5, LAZ3, ZBTB27, ZNF51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41182 (11-End)
      • expression tag (3-10)
      • engineered mutation (13)
      • engineered mutation (72)
      • engineered mutation (89)
  • Chain 'G':
    Compound: Nuclear receptor corepressor 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Nuclear receptor corepressor 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6xxsA (A:)
gpssdlylrpgdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacs
glfysiftdqlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqm
ehvvdtcrkfikase

    Sequence, based on observed residues (ATOM records):
    >6xxsA (A:)
sdlylrpgdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacsglf
ysiftdqlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqmehv
vdtcrkfika

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6xxsB (B:)
gpssdlylrpgdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacs
glfysiftdqlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqm
ehvvdtcrkfikase

    Sequence, based on observed residues (ATOM records):
    >6xxsB (B:)
pssdlylrpgdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacsg
lfysiftdqlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqme
hvvdtcrkfik

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6xxsC (C:)
gittikemgrsiheipr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6xxsD (D:)
gittikemgrsiheipr

    Sequence, based on observed residues (ATOM records):
    >6xxsD (D:)
ittikemgrsiheipr

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6xxsE (E:)
gpdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacsglfysiftd
qlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqmehvvdtcrk
fikase

    Sequence, based on observed residues (ATOM records):
    >6xxsE (E:)
dsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacsglfysiftdql
krnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqmehvvdtcrkfi
ka

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6xxsF (F:)
gpssdlylrpgdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacs
glfysiftdqlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqm
ehvvdtcrkfikase

    Sequence, based on observed residues (ATOM records):
    >6xxsF (F:)
sdlylrpgdsqiqftrhasdvllnlnrlrsrdiltdvvivvsreqfrahktvlmacsglf
ysiftdqlkrnlsvinldpeinpegfnilldfmytsrlnlregnimavmatamylqmehv
vdtcrkfik

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >6xxsG (G:)
gittikemgrsiheipr

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6xxsH (H:)
gittikemgrsiheipr

    Sequence, based on observed residues (ATOM records):
    >6xxsH (H:)
ittikemgrsiheipr