PDB entry 6xvk

View 6xvk on RCSB PDB site
Description: Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor bearing an acrylamide
Class: signaling protein
Keywords: type II kinase inhibitor, structure-based drug design, SIGNALING PROTEIN
Deposited on 2020-01-22, released 2020-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-17, with a file datestamp of 2020-06-12.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1, VEGFR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968
      • engineered mutation (134)
    Domains in SCOPe 2.08: d6xvka_
  • Heterogens: O3E, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xvkA (A:)
mdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtv
avkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnls
tylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnil
lseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvll
weifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfse
lvehlgnllqanaqqdenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6xvkA (A:)
pydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegathsehr
almselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykv
apedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgla
rdiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvk
ideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqana