PDB entry 6xva
View 6xva on RCSB PDB site
Description: Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor bearing an acrylamide
Class: signaling protein
Keywords: type II kinase inhibitor, structure-based drug design, SIGNALING PROTEIN
Deposited on
2020-01-21, released
2020-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-06-17, with a file datestamp of
2020-06-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
Species: Homo sapiens [TaxId:9606]
Gene: KIT, SCFR
Database cross-references and differences (RAF-indexed):
- Uniprot P10721 (Start-140)
- engineered mutation (22)
- engineered mutation (62)
- engineered mutation (84)
- engineered mutation (104)
- engineered mutation (115)
- linker (141-145)
- linker (155-158)
- Uniprot P10721 (159-End)
- engineered mutation (161)
- engineered mutation (197)
- engineered mutation (218)
- engineered mutation (237)
- engineered mutation (283)
- engineered mutation (287)
- engineered mutation (305)
- engineered mutation (316)
Domains in SCOPe 2.08: d6xvaa_ - Chain 'B':
Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
Species: Homo sapiens [TaxId:9606]
Gene: KIT, SCFR
Database cross-references and differences (RAF-indexed):
- Uniprot P10721 (Start-140)
- engineered mutation (62)
- engineered mutation (84)
- engineered mutation (104)
- engineered mutation (115)
- linker (141-145)
- linker (154-158)
- linker (146)
- Uniprot P10721 (159-End)
- engineered mutation (161)
- engineered mutation (197)
- engineered mutation (218)
- engineered mutation (237)
- engineered mutation (283)
- engineered mutation (287)
- engineered mutation (305)
- engineered mutation (316)
- Heterogens: O2K, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6xvaA (A:)
gshmpmyevqwkvveesngnnysyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taqgliksdaamtvavkmlkpsahsterealmselkvlsylgnhenivnllgacthggpt
lviteyccygdllnflrrkrdefvpykvapedlykdfltlehllsfsyqvakgmaflask
ncihrdlaarnillthgnitkicdfglardikndsnyvdkgnarlpvkwmapesifnsvy
tfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmsspeyapaemydimktc
wdadpdkrptfkqivqdiekqisestnh
Sequence, based on observed residues (ATOM records): (download)
>6xvaA (A:)
syidptqlpydhkwefprnrlsfgktlgagafgkvveataqgliksdaamtvavkmlkps
ahsterealmselkvlsylgnhenivnllgacthggptlviteyccygdllnflrrkrde
fvpydfltlehllsfsyqvakgmaflaskncihrdlaarnillthgnitkicdfglardi
kndsnyvdkgnarlpvkwmapesifnsvytfesdvwsygiflwelfslgsspypgmpvds
kfykmikegfrmsspeyapaemydimktcwdadpdkrptfkqivqdiekqises
- Chain 'B':
No sequence available.