PDB entry 6xva

View 6xva on RCSB PDB site
Description: Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor bearing an acrylamide
Class: signaling protein
Keywords: type II kinase inhibitor, structure-based drug design, SIGNALING PROTEIN
Deposited on 2020-01-21, released 2020-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-17, with a file datestamp of 2020-06-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10721 (Start-140)
      • engineered mutation (22)
      • engineered mutation (62)
      • engineered mutation (84)
      • engineered mutation (104)
      • engineered mutation (115)
      • linker (141-145)
      • linker (155-158)
    • Uniprot P10721 (159-End)
      • engineered mutation (161)
      • engineered mutation (197)
      • engineered mutation (218)
      • engineered mutation (237)
      • engineered mutation (283)
      • engineered mutation (287)
      • engineered mutation (305)
      • engineered mutation (316)
    Domains in SCOPe 2.08: d6xvaa_
  • Chain 'B':
    Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10721 (Start-140)
      • engineered mutation (62)
      • engineered mutation (84)
      • engineered mutation (104)
      • engineered mutation (115)
      • linker (141-145)
      • linker (154-158)
      • linker (146)
    • Uniprot P10721 (159-End)
      • engineered mutation (161)
      • engineered mutation (197)
      • engineered mutation (218)
      • engineered mutation (237)
      • engineered mutation (283)
      • engineered mutation (287)
      • engineered mutation (305)
      • engineered mutation (316)
  • Heterogens: O2K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xvaA (A:)
gshmpmyevqwkvveesngnnysyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taqgliksdaamtvavkmlkpsahsterealmselkvlsylgnhenivnllgacthggpt
lviteyccygdllnflrrkrdefvpykvapedlykdfltlehllsfsyqvakgmaflask
ncihrdlaarnillthgnitkicdfglardikndsnyvdkgnarlpvkwmapesifnsvy
tfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmsspeyapaemydimktc
wdadpdkrptfkqivqdiekqisestnh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xvaA (A:)
syidptqlpydhkwefprnrlsfgktlgagafgkvveataqgliksdaamtvavkmlkps
ahsterealmselkvlsylgnhenivnllgacthggptlviteyccygdllnflrrkrde
fvpydfltlehllsfsyqvakgmaflaskncihrdlaarnillthgnitkicdfglardi
kndsnyvdkgnarlpvkwmapesifnsvytfesdvwsygiflwelfslgsspypgmpvds
kfykmikegfrmsspeyapaemydimktcwdadpdkrptfkqivqdiekqises

  • Chain 'B':
    No sequence available.