PDB entry 6xv9

View 6xv9 on RCSB PDB site
Description: crystal structure of the kinase domain of human c-kit in complex with a type-ii inhibitor
Deposited on 2020-01-21, released 2020-05-27
The last revision was dated 2020-06-17, with a file datestamp of 2020-06-12.
Experiment type: XRAY
Resolution: 3.38 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10721 (Start-140)
      • engineered mutation (22)
      • engineered mutation (62)
      • engineered mutation (84)
      • engineered mutation (104)
      • engineered mutation (115)
      • linker (141-158)
    • Uniprot P10721 (159-End)
      • engineered mutation (161)
      • engineered mutation (197)
      • engineered mutation (218)
      • engineered mutation (237)
      • engineered mutation (283)
      • engineered mutation (287)
      • engineered mutation (305)
      • engineered mutation (316)
  • Chain 'B':
    Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10721 (Start-140)
      • engineered mutation (62)
      • engineered mutation (84)
      • engineered mutation (104)
      • engineered mutation (115)
      • linker (141-146)
      • linker (155-158)
    • Uniprot P10721 (159-End)
      • engineered mutation (161)
      • engineered mutation (197)
      • engineered mutation (218)
      • engineered mutation (237)
      • engineered mutation (283)
      • engineered mutation (287)
      • engineered mutation (305)
      • engineered mutation (316)
  • Heterogens: O35

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6xv9A (A:)
gshmpmyevqwkvveesngnnysyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taqgliksdaamtvavkmlkpsahsterealmselkvlsylgnhenivnllgacthggpt
lviteyccygdllnflrrkrdefvpykvapedlykdfltlehllsfsyqvakgmaflask
ncihrdlaarnillthgnitkicdfglardikndsnyvdkgnarlpvkwmapesifnsvy
tfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmsspeyapaemydimktc
wdadpdkrptfkqivqdiekqisestnh

    Sequence, based on observed residues (ATOM records):
    >6xv9A (A:)
nnysyidptqlpydhkwefprnrlsfgktlgagafgkvveataqgliksdaamtvavkml
kpsahsterealmselkvlsylgnhenivnllgacthggptlviteyccygdllnflrrk
rdefvpykvapedlykdfltlehllsfsyqvakgmaflaskncihrdlaarnillthgni
tkicdfglardikndsnyvdkgnarlpvkwmapesifnsvytfesdvwsygiflwelfsl
gsspypgmpvdskfykmikegfrmsspeyapaemydimktcwdadpdkrptfkqivqdie
kqises

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6xv9B (B:)
gshmpmyevqwkvveesngnnysyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taqgliksdaamtvavkmlkpsahsterealmselkvlsylgnhenivnllgacthggpt
lviteyccygdllnflrrkrdefvpykvapedlykdfltlehllsfsyqvakgmaflask
ncihrdlaarnillthgnitkicdfglardikndsnyvdkgnarlpvkwmapesifnsvy
tfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmsspeyapaemydimktc
wdadpdkrptfkqivqdiekqisestnh

    Sequence, based on observed residues (ATOM records):
    >6xv9B (B:)
dptqlpydhkwefprnrlsfgktlgagafgkvveataqgliksdaamtvavkmlkpsahs
terealmselkvlsylgnhenivnllgacthggptlviteyccygdllnflrrkrdefvp
ykdfltlehllsfsyqvakgmaflaskncihrdlaarnillthgnitkicdfglardikn
dsnyvdkgnarlpvkwmapesifnsvytfesdvwsygiflwelfslgsspypgmpvdskf
ykmikegfrmsspeyapaemydimktcwdadpdkrptfkqivqdiekqises